Lorazepam

Lorazepam structural formula

CAS Number846-49-1
Molecular FormulaC15H10Cl2N2O2
Molecular Weight321.161
InChI KeyDIWRORZWFLOCLC-UHFFFAOYSA-N
LogP2.39
Synonyms
  • Lorazepam
  • 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
  • 846-49-1
  • 5-25-02-00248
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
  • (.+-.)-Lorazepam
  • (RS)-Lorazepam
  • 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
  • 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
  • 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
  • Almazine
  • Anxiedin
  • Anzepam
  • Aplacasse
  • Aplacassee
  • Apo-Lorazepam
  • Azurogen
  • Bonatranquan
  • Delormetazepam
  • Demethyllormetazepam
  • Duralozam
  • Efasedan
  • Emotival
  • Equitam
  • Kalmalin
  • Larpose
  • Laubeel
  • Lorabenz
  • Lorapam
  • Lorazene
  • Lorazep
  • Lorazin
  • Lorazon
  • Lorenin
  • Loridem
  • Lorivan
  • Lorsedal
  • Lorsilan
  • Lozepam
  • Nervistop L
  • Norlormetazepam
  • Novhepar
  • Novo-lorazem
  • NSC 289758
  • o-Chlorooxazepam
  • o-Chloroxazepam
  • Orfidal
  • Pro Dorm
  • Psicopax
  • Punktyl
  • Renaquil
  • Rocosgen
  • Securit
  • Sedatival
  • Sedazin
  • Sedizepan
  • Sidenar
  • Silence
  • Sinestron
  • Somagerol
  • Tavor Expidet
  • Temesta
  • Tranqipam
  • BRN 0759084
  • 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
  • EINECS 212-687-6
  • Emotion
  • Idalprem
  • Lomesta
  • Lorazepam Fabra
  • Lorazepam Genericon
  • Lorazepam Lannacher
  • Lorazepam Medical
  • Lorazepam-Efeka
  • Lorazepan Chobet
  • Lorazepan Richet
  • Max Pax
  • Nervistopl
  • Novolorazem
  • Nu Loraz
  • Vigiten
  • Lorafen
  • Lorazepam intensol
  • Lorazepam preservative free
  • Lorazepamum
  • UNII-O26FZP769L

Applications:

HPLC Method for Lorazepam Injection on Newcrom R1 Column

July 22, 2021

Separation type: Liquid Chromatography Reverse Phase.





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High Performance Liquid Chromatography (HPLC) Method for Analysis of  Lorazepam.




Lorazepam is a short-acting benzodiazepine medication commonly used as a sedative and anxiolytic of choice in the inpatient setting owing to its fast onset of action when administered intravenously. Lorazepam is one of the few sedative-hypnotics with a relatively clean side effect profile. Lorazepam can be retained in HPLC on Newcrom R1 reverse-phase column with the simple isocratic mobile phase consisting of acetonitrile (MeCN) and water. The analysis method can be UV detected at 275 nm.



Condition
Column Newcrom R1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 35%
Buffer No
Flow Rate 1.0 ml/min
Detection 275 nm

Description
Class of Compounds Hydrophobic, Drug
Analyzing Compounds Benzyl Alchohol, Lorazepam

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Benzyl alcohol
Lorazepam
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Lorazepam on Newcrom R1 HPLC column

February 19, 2018
Separation of Lorazepam on Newcrom C18 HPLC column

Lorazepam can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Lorazepam
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.