HPLC Method for Determination of Triazolam on Newcrom R1 Column

HPLC Method for Triazolam on Newcrom R1 by SIELC Technologies

HPLC Method for Determination of Triazolam on Newcrom R1 Column      

High Performance Liquid Chromatography (HPLC) Method for Analysis of Triazolam.

Triazolam is a prescription-strength benzodiazepine with the chemical formula C17H12Cl2N4. It is used to treat insomnia, as it is a central nervous system depressant tranquilizer. Compared to other benzodiazepines, it is fairly obscure, preventing misuse and abuse of it. It is a Schedule IV drug.

Triazolam can be retained and analyzed on a Newcrom R1 reverse-phase column using a simple isocratic analytical method with a mobile phase consisting of Acetonitrile (MeCN), water, and Sulfuric acid as the ionic modifier. This analysis method can be UV detected at 200 nm with high resolution and peak symmetry.

Condition
Column Newcrom R1, 2.1 x 100 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN – 35%
Buffer H2SO4 – 0.2%
Flow Rate 0.2 ml/min
Detection UV 210 nm

 

Description
Class of Compounds Drug
Analyzing Compounds Triazolam

Application Column

Newcrom R1

Column Diameter: 2.1 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Triazolam
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.