Doxazosin mesylate

CAS Number77883-43-3
Molecular FormulaC24H29N5O8S
Molecular Weight547.581
InChI KeyVJECBOKJABCYMF-UHFFFAOYSA-N
LogP1.66
Synonyms
  • Doxazosin mesylate
  • Methanesulfonic acid--[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](2,3-dihydro-1,4-benzodioxin-2-yl)methanone (1/1)
  • Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2,3-dihydro-1,4-benzodioxin-2-yl)-, methanesulfonate (1:1)
  • 77883-43-3
  • Cardura
  • Cardura XL
  • Alfadil
  • Cardenalin
  • Cardoral
  • Cardoxan
  • Cardular
  • Cardular PP
  • Cardular Uro
  • Carduran
  • Dedralen
  • Diblocin
  • Diblocin PP
  • Diblocin Uro
  • Doksura
  • Doxaben
  • Doxazomerck
  • Doxazosin AZU
  • Doxolbran
  • Kaltensif
  • Normathen
  • Progandol
  • Prostadilat
  • Supressin
  • Tensiobas
  • Tonocardin
  • UNII-86P6PQK0MU
  • Duracin
  • Doxazocine
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine monomethanesulfonate

Applications:

HPLC Method for Analysis of Doxazosin Mesylate in Tablets

June 7, 2018

HPLC Method for Doxazosin mesylate on Newcrom R1 by SIELC Technologies

HPLC Method for Analysis of Doxazosin Mesylate in Tablets_Chr_1133

High Performance Liquid Chromatography (HPLC) Method for Analysis of Doxazosin mesylate

Doxazosin is a quinazoline derivative with the molecular formula of C23H25N5O5 • CH3SO3H. It is primarily used as a prescription medication for treatment of hypertension and its symptoms. It is an alpha-blocker that relaxes blood vessels and muscles.

Doxazosin mesylate can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a triethanolamine buffer. Detection is performed using UV.

ColumnNewcrom R1, 4.6 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 25/75%
BufferTEAPh – 50 mM
Flow Rate1.0 ml/min
DetectionUV, 270 nm
Class of Compounds
Drug, Hydrophobic, Neutral
Analyzing CompoundsDoxazosin mesylate

Application Column

Newcrom R1

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Doxazosin mesylate
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.