Sulfamethoxazole

85

CAS Number723-46-6
Molecular FormulaC10H11N3O3S
Molecular Weight253.276
InChI KeyJLKIGFTWXXRPMT-UHFFFAOYSA-N
LogP0.9
Synonyms
  • Sulfamethoxazole
  • Sulphamethoxazole
  • Sulfisomezole
  • Gantanol
  • Sulfamethoxazol
  • Metoxal
  • Sulfamethylisoxazole
  • Simsinomin
  • Radonil
  • Sinomin
  • Sulphamethoxazol
  • Sulpha-methoxizole
  • Sulfamethalazole
  • Azo-gantanol
  • 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
  • Sulphamethylisoxazole
  • Urobak
  • Sulfamethoxizole
  • 3-Sulfanilamido-5-methylisoxazole
  • Gantanol-DS
  • 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
  • Bactrimel
  • Gamazole
  • Azo gantanol
  • Sulfametoxazol
  • Sulphisomezole
  • Solfametossazolo
  • Sulfamethoxazolum
  • 5-Methyl-3-sulfanilamidoisoxazole
  • Ro 4-2130
  • MS 53
  • 3-Sulphanilamido-5-methylisoxazole
  • Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-
  • 5-Methyl-3-sulphanil-amidoisoxazole
  • 3-(p-Aminophenylsulfonamido)-5-methylisoxazole
  • 5-Methyl-3-sulfanylamidoisoxazole
  • N'-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N1-(5-Methyl-3-isoxazolyl)sulfanilamide
  • N'-(5-Methylisoxazol-3-yl)sulphanilamide
  • EINECS 211-963-3
  • 129378-89-8
  • 3-(p-Aminobenzenesulfonamido)-5-methylisoxazole
  • BRN 0226453
  • NSC 147832
  • 4-Amino-N-(5-methyl-3-isoxazolyl)benzensulfonamide
  • Gantanol (TN)
  • 723-46-6
  • 3-(para-Aminophenylsulphonamido)-5-methylisoxazole
  • UNII-JE42381TNV
  • sulfametoxazol
  • N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide
  • Sulfanilamide, N(1)-(5-methyl-3-isoxazolyl)-
  • Sulfanilamide, N1-(5-methyl-3-isoxazolyl)-
  • 4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzene-1-sulfonamide
  • SMX

Applications:

HPLC Method For Analysis Of Sulfamethoxazole and Trimethoprim on Primesep 100 Column

March 22, 2022

Separation type: Liquid Chromatography Mixed-mode


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High Performance Liquid Chromatography (HPLC) Method for Analysis of Sulfamethoxazole and Trimethoprim

Condition

Column Primesep 100, Newcrom R1 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 40/60%
Buffer H2SO4 – 0.4%
Flow Rate 1.0 ml/min
Detection UV, 200 nm,

 

Description

Class of Compounds
Drug
Analyzing Compounds Sulfamethoxazole, Trimethoprim

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:

Sulfamethoxazole
Trimethoprim
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Antibiotics in Mixed-mode chromatography

May 11, 2015

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).

 

Condition

Column Obelisc R, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid – 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
 Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

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Application Analytes:
Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin

Application Detection:
ELSD Detection
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.