Sulphaguanidine

Sulphaguanidine structural formula

CAS Number57-67-0
Molecular FormulaC7H10N4O2S
Molecular Weight214.241
InChI KeyBRBKOPJOKNSWSG-UHFFFAOYSA-N
LogP-0.798
Synonyms
  • Sulfaguanidine
  • 4-Amino-N-carbamimidoylbenzene-1-sulfonamide
  • Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-
  • 57-67-0
  • Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)-
  • [(p-Aminophenyl)sulfonyl]guanidine
  • 1-[(p-Aminophenyl)sulfonyl]guanidine
  • 1-Sulfanilylguanidine
  • 4-Aminobenzenesulfonylguanidine
  • 4-Amino-N-(aminoiminomethyl)benzenesulfonamide
  • 4-Aminophenylsulfonylguanidine
  • Abiguanil
  • Aterian
  • Ganidan
  • Guamide
  • Guanicil
  • Guanidan
  • N1-Amidinosulfanilamide
  • N1-Guanidylsulfanilamide
  • N1-Guanylsulfanilamide
  • N-Guanylsulfanilamide
  • NSC 14041
  • Orgaguanidon
  • p-Aminobenzenesulfoguanidide
  • p-Aminobenzenesulfonylguanidine
  • Resulfon
  • Shigatox
  • Suganyl
  • Sulfaguanidin
  • sulfaguanidina
  • Sulfaguanil
  • Sulfaguine
  • Sulfanilamide, N1-(diaminomethylene)-
  • Sulfanilamide, N1-amidino-
  • Sulfanilguanidine
  • Sulfanilylguanidine
  • Sulfentidine
  • Sulfoguanidine
  • Sulfoguanil
  • Sulfoguanyl
  • Sulfoguenil
  • Sulphaguanidine
  • N-p-Aminobenzenesulphonylguanidine monohydrate
  • 4-Amino-N-(diaminomethylene)benzenesulfonamide
  • ((p-Aminophenyl)sulfonyl)guanidine
  • 1-((p-Aminophenyl)sulfonyl)guanidine
  • ((4-Aminophenyl)sulfonyl)guanidine
  • EINECS 200-345-9
  • S-Guanidine
  • Guanidine, sulfanilyl-
  • Sulfanilamide, N(sup1)-amidino-
  • Sulfoquanidine
  • Sulginum
  • N(sup 1)-Amidinosulfanilamide
  • N(sup 1)-(Diaminomethylene)sulfanilamide
  • N(sup 1)-Guanylsulfanilamide
  • Solfaguanidina
  • Sulfaguanidinum
  • UNII-15XQ8043FN
  • 61116-95-8

Applications:

Separation of Antibiotics in Mixed-mode chromatography

May 11, 2015

 

A complex mixture of sulphonamide, macrolide, tetracycline and fluoroquinolone antibiotics were separated in one run using mixed-mode chromatography with LC/MS -compatible conditions. All compounds are separated based on reversed-phase and/or ion-exchange mechanism. Method can be used for analysis of various classes of antibiotics and related impurities in different sample matrices (blood, urine, soil, waste water).

 

Condition
Column Obelisc R, 2.1×150 mm, 5 µm, 100A
Mobile Phase Gradient MeCN – 0-25%, 6 min, 25-70% 14 min
Buffer Gradient Formic Acid – 0.05%-0.3%, 10 min, 14 min hold
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description
Class of Compounds
  Antibiotic, Drug, Hydrophobic, Ionizable
Analyzing Compounds Sulphanilamide, Sulphaguanidine, Oxytetracycline, Marbofloxacin, Sulphadiazine, Chlortetracycline, Nofloxacin, Spiramycin, Cefalonium, Tylosin, Josamycin, Sulphamethoxazole, Dapsone, Sulphaquinoxalline, Flumequine

 

Application Column

Obelisc R

SIELC has developed the Obelisc™ columns, which are mixed-mode and utilize Liquid Separation Cell technology (LiSC™). These cost-effective columns are the first of their kind to be commercially available and can replace multiple HPLC columns, including reversed-phase (RP), AQ-type reversed-phase, polar-embedded group RP columns, normal-phase, cation-exchange, anion-exchange, ion-exclusion, and HILIC (Hydrophilic Interaction Liquid Chromatography) columns. By controlling just three orthogonal method parameters - buffer concentration, buffer pH, and organic modifier concentration - users can adjust the column properties with pinpoint precision to separate complex mixtures.

Select options
Application Analytes:
Carboxymethylcysteine
Chlortetracycline
Dapsone
Flumequine
Josamycin
Marbofloxacin
Norfloxacin
Oxytetracycline
Spiramycin
Sulfamethoxazole
Sulfonamides
Sulphadiazine
Sulphaguanidine
Sulphanilamide
Sulphaquinoxaline
Tetracycline
Tylosin
Application Detection:
ELSD Detection
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.