Cephalexin

Cephalexin structural formula

CAS Number15686-71-2
Molecular FormulaC16H17N3O4S
Molecular Weight347.391
InChI KeyZAIPMKNFIOOWCQ-UEKVPHQBSA-N
LogP0.65
Synonyms
  • Cephalexin
  • (6R,7R)-7-{[(2R)-2-Amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-
  • 15686-71-2
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-aminophenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-, D-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-, [6R-[6?,7?(R*)]]-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-
  • 7-(D-?-Amino-?-phenylacetoamido)-3-methyl-3-cephem-4-carboxylic acid
  • 7-(?-Amino-D-phenylacetamido)-3-deacetoxycephalosporanic acid
  • 7-[(Aminophenylacetyl)amino]-3-dimethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 7-[D-(-)-?-Aminophenylacetamido]-3-methyl-3-cephem-4-carboxylic acid
  • Alcephin
  • Alsporin
  • Carnosporin
  • Cefablan
  • Cefadal
  • Cefadin
  • Cefadina
  • Cefadros
  • Cefadyl
  • Cefaleksin
  • cefalexin
  • cefalexina
  • cefalexine
  • Cefalin
  • Cefaloto
  • Cefanex
  • Cefaseptin
  • Ceforal
  • Cefovit
  • Celexin
  • Cepastar
  • Cepexin
  • Cephacillin
  • Cephalexine
  • CEPHALOSPORANIC ACID, 7-(D-?- AMINOPHENYLACETAMIDO)DESACETOXY-
  • Cephamasten
  • Cephaxin
  • Ceporex
  • Ceporex Forte
  • Ceporexin
  • Ceporexine
  • Cerexin
  • Cophalexin
  • D-Cephalexin
  • Derantel
  • Durantel
  • Durantel DS
  • Ed A-Ceph
  • Efalexin
  • Erocetin
  • Farexin
  • Felexin
  • Garasin
  • Ibrexin
  • Inphalex
  • Iwalexin
  • Kefalex
  • Kefalospes
  • Kefaxin
  • Kefexin
  • Kefloridina
  • Keforal
  • Kekrinal
  • Kidolex
  • Lafarine
  • Lenocef
  • Lexibiotico
  • Lilly 66873
  • L-Keflex
  • Llonexina
  • Lonflex
  • Lopilexin
  • Madlexin
  • Mamalexin
  • Mamlexin
  • Mecilex
  • Medoxine
  • Naxifelar
  • Novolexin
  • Ohlexin
  • Oracocin
  • Oriphex
  • Ospexin
  • Palitrex
  • Pectril
  • Pyassan
  • Rinesal
  • Sanaxin
  • Sencephalin
  • Sepexin
  • Septilisin
  • Servispor
  • Sialexin
  • Sinthecillin
  • Sintolexyn
  • Sporicef
  • Sporidex
  • Taicelexin
  • Tepaxin
  • Tokiolexin
  • Uphalexin
  • 7-(D-2-Amino-2-phenylacetamido)-3-methyl-delta (sup 3)-cephem-4- carboxylic acid
  • 7-(D-2-Amino-2-phenylacetamido)-3-methyl-delta3-cephem-4-carboxylic acid
  • 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid
  • BRN 0965503
  • Cefa-iskia
  • Cephalexinum
  • Cephanasten
  • EINECS 239-773-6
  • Larixin
  • Neolexina
  • Ortisporina
  • Sartosona
  • (6R,7R)-7-((R)-2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure
  • Ceporexin-E
  • Factagard
  • Kefolan
  • Roceph Distab
  • Zozarine
  • Panixine disperdose
  • Cefalessina
  • Cefalexinum
  • UNII-5SFF1W6677
  • Cephalexin anhydrous
  • Optocef
  • (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 7-(D-alpha-Aminophenylacetamido)desacetoxycephalosporanic acid
  • 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acid
  • CEX

Applications:

HPLC Separation of β-Lactam Antibiotics on Primesep 100 Column

2021-03-18

Separation type: Liquid Chromatography Mixed-mode

HPLC.cloud View on hplc.cloud



High Performance Liquid Chromatography (HPLC) Method for Analysis of Amoxicillin and Cephalexin. Both amoxicillin and cephalexin are beta-lactam antibiotics. Beta-lactam antibiotics contain a beta-lactam ring in their molecular structure. As a group, these drugs are active against many gram-positive, gram-negative and anaerobic organisms. Both compounds can be retained and baseline separated with an isocratic method in 30/70 Acetonitrile (ACN) and water mobile phase with a Sulfuric acid (H2SO4) buffer. UV detection at 250 nm.

Condition

Column Primesep 100, 4.6x100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O
Buffer TFA, H2SO4
Flow Rate 1.0 ml/min
Detection UV, 250 nm
 

Description

Class of Compounds Drug, Antibiotics, Hydrophobic, Ionizable
Analyzing Compounds Cephalexin,  Amoxicillin
 
Application Analytes:
Amoxicillin
Amoxicillin hydrate (1:3)
Cephalexin

Separation of Cephalexin on Newcrom R1 HPLC column

2018-05-16
Separation of Cephalexin on Newcrom R1 HPLC column

Cephalexin can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com" or by phone: 847-229-2629.

Application Analytes:
Cephalexin