Alprazolam

Alprazolam structural formula

CAS Number28981-97-7
Molecular FormulaC17H13ClN4
Molecular Weight308.770
InChI KeyVREFGVBLTWBCJP-UHFFFAOYSA-N
LogP2.12
Synonyms
  • Alprazolam
  • 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-methyl-6-phenyl-
  • 28981-97-7
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-methyl-6-phenyl-
  • 4H-s-Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-1-methyl-6-phenyl-
  • 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • 8-Chloro-1-methyl-6-phenyl-4H-2,3,5,10b-tetraazabenzo[e]azulene
  • 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • Alcelam
  • Alpralid
  • Alprazolam Intensol
  • Alprozolam
  • Altraxic
  • Alzolam
  • Anpress
  • Ansiopax
  • Apo-Alpraz
  • Cassadan
  • Constan
  • Frontal
  • Pharnax
  • Ralozam
  • Relaxol
  • Solanax
  • Tafil D
  • Tensivan
  • Trankimazin
  • Tranquinal
  • Tricalma
  • Valeans
  • Xanagis
  • Xanax TS
  • Xanolam
  • Zolarem
  • Alprazolamum
  • BRN 1223125
  • 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
  • EINECS 249-349-2
  • Xanax XR
  • Alpronax
  • Bestrol
  • Esparon
  • Gen-Alprazolan
  • Intensol
  • Novo-Alprazol
  • Nu-Alpraz
  • Prazolan
  • Zacetin
  • Zanapam
  • Alprazolam extended release tablets
  • Niravam
  • UNII-YU55MQ3IZY
  • Xanax

Applications:

HPLC Method For Analysis Of Alprazolam on Newcrom R1 Column

May 22, 2018

HPLC Method for Alprazolam on Newcrom R1 by SIELC Technologies

HPLC Method for Analysis of Alprazolam

High Performance Liquid Chromatography (HPLC) Method for Analysis of Alprazolam

Alprazolam, also known as Xanax, is a perscription medication with the C17H13ClN4 molecular formula. It is typically used to treat anxiety and panic disorders. It works through enhancing the effects of GABA, which is a calming neurotransmitter in the brain.

Alprazolam can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric acid buffer. Detection is performed using UV.

ColumnNewcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 30/70%
BufferH3PO4 – 0.2%
Flow Rate0.5 ml/min
DetectionUV, 250 nm
Class of Compounds
Drug, Sedative, Hydrophobic, Neutral, Acid
Analyzing CompoundsAlprazolam

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Alprazolam
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.