HPLC Method For Analysis Of Alprazolam on Newcrom R1 Column

HPLC Method for Analysis of Alprazolam


Column Newcrom R1, 3.2×100 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 30/70%
Buffer H3PO4 – 0.2%
Flow Rate 0.5 ml/min
Detection UV, 250 nm



Class of Compounds
Drug, Sedative, Hydrophobic, Neutral, Acid
Analyzing Compounds Alprazolam


Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.