| CAS Number | 134523-00-5 |
|---|---|
| Molecular Formula | C33H35FN2O5 |
| Molecular Weight | 558.650 |
| InChI Key | XUKUURHRXDUEBC-KAYWLYCHSA-N |
| LogP | 5.04 |
| Synonyms |
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Applications:
HPLC Method for Analysis of Atorvastatin
May 31, 2018
HPLC Method for Atorvastatin, Lipitor on Newcrom R1 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Atorvastatin, Lipitor
Atorvastatin is a prescription medication that has C33H35FN2O5 as its molecular formula. It is typically used to lower cholesterol, therefore reducing the risk of heart disease. Grapefruit juice can interfere with this medication.
Atorvastatin, Lipitor can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric acid buffer. Detection is performed using UV.
| Column | Newcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H3PO4 – 0.1 % |
| Flow Rate | 0.5 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds | Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Lipitor |
Application Column
Newcrom R1
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Lipitor
HPLC Method for Analysis of Lipitor
May 6, 2016
| Column | Primesep 200, 3.2×100 mm, 5 µm, 100A |
| Mobile Phase | Gradient MeCN – 30-65%, 5 min, 4 min hold |
| Buffer | Gradient H3PO4 0.05 – 0.3% , 5 min, 4 min hold |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsLipitor
HPLC Separation of Fungicides in a Green Tea Matrix
May 27, 2015
Even though teas are known for containing polyphenols such as catechins, flavonoids and theaflavins, SIELC mixed-mode columns can be used to analyze a matrix from a commercial tea and retain target compounds. In this method, green tea was spiked with 0.005mg/ml of pesticides previously found in teas. Primesep 200 was used for it’s reverse-phase and acidic ion-pairing groups. Target compounds were retained and resolved from the majority of the tea matrix peak.
| Column | Primesep 200, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 50/50% |
| Buffer | H3PO4 – 0.05 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Picoxystrobin, Pyrimethanil, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPicoxystrobin
Pyrimethanil
HPLC Separation of Agricultural Compounds Found in Tea
May 27, 2015
Tea has been known to contain residue of pesticides and fungicides such as picoxystrobin and pyrimethanil. We used Primesep 200, a reversed-phase column with weakly acidic ion-pairing groups to separate picoxystrobin, pyrimethanil and atorvastatin. A 15 minute method used to demonstrate retention control when adjusting ratio of organic to aqueous in the mobile phase. Baseline retention with good resolution was achieved.
| Column | Primesep 200, 4.6×150 mm, 5 µm, 100A |
| Mobile Phase | MeCN/H2O – 45/55%, MeCN/H2O – 50/50% |
| Buffer | H2SO4 – 0.1 % |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 250 nm |
| Class of Compounds |
Drug, Statin, Hydrophobic, Ionizable |
| Analyzing Compounds | Atorvastatin, Picoxystrobin, Pyrimethanil, Lipitor |
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsPicoxystrobin
Pyrimethanil
