HPLC Method for Atorvastatin, Lipitor on Newcrom R1 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Atorvastatin, Lipitor
Atorvastatin is a prescription medication that has C33H35FN2O5 as its molecular formula. It is typically used to lower cholesterol, therefore reducing the risk of heart disease. Grapefruit juice can interfere with this medication.
Atorvastatin, Lipitor can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric acid buffer. Detection is performed using UV.
Column | Newcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended |
Mobile Phase | MeCN/H2O – 50/50% |
Buffer | H3PO4 – 0.1 % |
Flow Rate | 0.5 ml/min |
Detection | UV, 270 nm |
Class of Compounds | Drug, Statin, Hydrophobic, Ionizable |
Analyzing Compounds | Atorvastatin, Lipitor |
Application Column
Newcrom R1
Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Lipitor