| CAS Number | 22161-81-5 |
|---|---|
| Molecular Formula | C16H14O3 |
| Molecular Weight | 254.285 |
| InChI Key | DKYWVDODHFEZIM-NSHDSACASA-N |
| LogP | 3.1 |
| Synonyms |
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Applications:
UV-Vis Spectrum of Dexketoprofen
July 11, 2024
For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
HPLC Method for Analysis of Dexketoprofen on Primesep B Column
March 6, 2024
HPLC Method for Analysis of Dexketoprofen on Primesep B Column by SIELC Technologies
Separation type: Liquid Chromatography Reversed-phase
Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid class. It is the active enantiomer of ketoprofen, meaning it is one of the mirror-image forms of the ketoprofen molecule. Dexketoprofen is used for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties.
Medical professionals commonly prescribe dexketoprofen for the short-term management of acute pain, such as postoperative pain or musculoskeletal pain. It works by inhibiting the production of certain chemicals in the body, called prostaglandins, which are involved in the inflammatory response and the perception of pain.
It’s important to note that like all NSAIDs, dexketoprofen can have potential side effects, including gastrointestinal issues such as stomach upset or ulcers, so it should be used under the supervision of a healthcare provider, and the prescribed dosage and duration should be followed accordingly.
Dexketoprofen can be retained and analyzed on a reversed-phase Primesep B column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid. This analytical method can be detected with high resolution and peak symmetry at a wavelength of 220 nm using UV detection
High Performance Liquid Chromatography (HPLC) Method for Analyses of Dexketoprofen on Primesep B Column by SIELC Technologies
Condition
| Column | Primesep B, 4.6 x 150 mm, 5 µm, 100 A |
| Mobile Phase | MeCN/H2O – 45/55% |
| Buffer | H2SO4 – 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV 255 nm |
Description
| Class of Compounds | Drug |
| Analyzing Compounds | Dexketoprofen |
Application Column
Primesep B
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
