Dexketoprofen

CAS Number 22161-81-5
Molecular Formula C16H14O3
Molecular Weight254.285
InChI KeyDKYWVDODHFEZIM-NSHDSACASA-N
LogP3.1
Synonyms
  • DEXKETOPROFEN
  • 22161-81-5
  • (S)-(+)-Ketoprofen
  • (S)-Ketoprofen
  • (+)-Ketoprofen
  • (S)-2-(3-benzoylphenyl)propanoic acid
  • (2S)-2-(3-benzoylphenyl)propanoic acid
  • S-(+)-Ketoprofen
  • Dexketoprofen [INN]
  • Arveles
  • (+)-3-Benzoylhydratropic acid
  • (+)-(S)-m-Benzoylhydratropic acid
  • Hydratropic acid, m-benzoyl-, (+)-
  • Ketoprofen, (s)-
  • (S)-3-Benzoyl-alpha-methylbenzeneacetic acid
  • CHEMBL75435
  • (S)-(+)-2-(3-Benzoylphenyl)propionic acid
  • CHEBI:76128
  • 6KD9E78X68
  • MFCD00673316
  • Dexketoprofen (INN)
  • (2S)-2-[3-(benzenecarbonyl)phenyl]propanoic acid
  • SMR000857177
  • (S)-Ketoprofen;Dexketoprofen
  • Dexketoprofen [INN:BAN]
  • UNII-6KD9E78X68
  • 9KL
  • (S)-2-(3-Benzoylphenyl)propionic acid
  • BiomolKI_000007
  • (S)-(+)-Ketoprofen?
  • BiomolKI2_000017
  • SCHEMBL66987
  • BMK1-B7
  • MLS001333189
  • MLS001333190
  • Benzeneacetic acid, 3-benzoyl-alpha-methyl-, (S)-
  • DEXKETOPROFEN [WHO-DD]
  • (S)-(+)-Ketoprofen, 99%
  • DTXSID40905141
  • DKYWVDODHFEZIM-NSHDSACASA-N
  • HMS2090M22
  • HMS2234M14
  • BCP13810
  • HY-B2137
  • BDBM50088570
  • s5192
  • 2-(3-Benzoyl-phenyl)-propionic acid
  • AKOS015913672
  • AC-8103
  • CCG-100611
  • CS-8173
  • DB09214
  • NCGC00142585-01
  • NCGC00142585-02
  • AS-17683
  • BK166230
  • (S)-2-(3-Benzoyl-phenyl)-propionic acid
  • NS00121038
  • (+)-2-(3-BENZOYLPHENYL)PROPIONIC ACID
  • (S)-(+)-2-(3-benzoylphenyl) propionic acid
  • (S)-(+)-3-Benzoyl-?-methylbenzeneacetic Acid
  • D07269
  • D94685
  • (2S)-2-(3-BENZOYLPHENYL)PROPIONIC ACID
  • (S)-(+)-3-Benzoyl-alpha-methylbenzeneacetic 5
  • AB00918363-05
  • EN300-7359590
  • (S)-(+)-3-Benzoyl-alpha-methylbenzeneacetic acid
  • A878675
  • Q425440
  • S-(+)-Ketoprofen; (S)-ketoprofen; Dexketoprofen
  • W-201922
  • (.ALPHA.S)-3-BENZOYL-.ALPHA.-METHYLBENZENEACETIC ACID
  • Benzeneacetic acid, 3-benzoyl-.alpha.-methyl-, (.alpha.S)-
  • BENZENEACETIC ACID, 3-BENZOYL-.ALPHA.-METHYL-, (S)-
  • Benzeneacetic acid, 3-benzoyl-?-methyl-, (S)-Hydratropic acid, m-benzoyl-, (+)-

Applications:

UV-Vis Spectrum of Dexketoprofen

July 11, 2024
UV-Vis Spectrum of Dexketoprofen. Absorption Maxima: 256 nm.

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.

Application Analytes:
Dexketoprofen
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Dexketoprofen on Primesep B Column

March 6, 2024

HPLC Method for Analysis of Dexketoprofen on Primesep B Column by SIELC Technologies

Separation type: Liquid Chromatography Reversed-phase

HPLC Method for Analysis of Dexketoprofen on Primesep B Column
HPLC Method for Analysis of Dexketoprofen on Primesep B Column by SIELC Technologies


Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the propionic acid class. It is the active enantiomer of ketoprofen, meaning it is one of the mirror-image forms of the ketoprofen molecule. Dexketoprofen is used for its analgesic (pain-relieving), anti-inflammatory, and antipyretic (fever-reducing) properties.

Medical professionals commonly prescribe dexketoprofen for the short-term management of acute pain, such as postoperative pain or musculoskeletal pain. It works by inhibiting the production of certain chemicals in the body, called prostaglandins, which are involved in the inflammatory response and the perception of pain.

It’s important to note that like all NSAIDs, dexketoprofen can have potential side effects, including gastrointestinal issues such as stomach upset or ulcers, so it should be used under the supervision of a healthcare provider, and the prescribed dosage and duration should be followed accordingly.

Dexketoprofen can be retained and analyzed on a reversed-phase Primesep B column with a mobile phase consisting of water, Acetonitrile (MeCN), and sulfuric acid. This analytical method can be detected with high resolution and peak symmetry at a wavelength of 220 nm using UV detection

High Performance Liquid Chromatography (HPLC) Method for Analyses of Dexketoprofen on Primesep B Column by SIELC Technologies

Condition

ColumnPrimesep B, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 45/55%
BufferH2SO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 255 nm

Description

Class of CompoundsDrug
Analyzing CompoundsDexketoprofen

Application Column

Primesep B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Dexketoprofen
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.