Dimethylethanolamine (DMAE or DMEA)

CAS Number108-01-0
Molecular Formula C4H11NO
Molecular Weight89.14
InChI KeyUEEJHVSXFDXPFK-UHFFFAOYSA-N
LogP-0.4
Synonyms
  • 2-(Dimethylamino)ethanol
  • Deanol
  • N,N-Dimethylethanolamine
  • 108-01-0
  • Dimethylethanolamine
  • Dimethylaminoethanol
  • 2-DIMETHYLAMINOETHANOL
  • Norcholine
  • DMAE
  • Bimanol
  • Liparon
  • Varesal
  • N,N-Dimethylaminoethanol
  • Propamine A
  • DMEA
  • Ethanol, 2-(dimethylamino)-
  • (2-Hydroxyethyl)dimethylamine
  • Kalpur P
  • Dimethylmonoethanolamine
  • Dimethylaminoaethanol
  • N,N-Dimethyl-2-hydroxyethylamine
  • Amietol M 21
  • N,N-Dimethyl-2-aminoethanol
  • N-Dimethylaminoethanol
  • Texacat DME
  • N,N-Dimethyl ethanolamine
  • 2-(N,N-Dimethylamino)ethanol
  • Dimethyl(hydroxyethyl)amine
  • Dimethylaethanolamin
  • Dimethyl(2-hydroxyethyl)amine
  • 2-(Dimethylamino)-1-ethanol
  • N-(2-Hydroxyethyl)dimethylamine
  • Demanol
  • Demanyl
  • N,N-Dimethyl-N-(2-hydroxyethyl)amine
  • (Dimethylamino)ethanol
  • beta-Hydroxyethyldimethylamine
  • beta-Dimethylaminoethyl alcohol
  • 2-(Dimethylamino) ethanol
  • 2-Dwumetyloaminoetanolu
  • 2-Dimethylamino-ethanol
  • N,N-Dimethyl-N-(beta-hydroxyethyl)amine
  • NSC 2652
  • CCRIS 4802
  • N-(Dimethylamino)ethanol
  • Oristar dmae
  • HSDB 1329
  • N,N-Dimethyl(2-hydroxyethyl)amine
  • Tegoamin DMEA

Applications:

ELSD HPLC Method for Analysis of Dimethylethanolamine (DMAE or DMEA) on Primesep 100  Column

January 17, 2025

HPLC Method for Dimethylethanolamine (DMAE or DMEA) on Primesep 100 by SIELC Technologies

HPLC Method for Analysis of Dimethylethanolamine (DMAE or DMEA) on Primesep 100 Column by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Dimethylethanolamine (DMAE or DMEA)

Dimethylethanolamine (DMAE or DMEA) is a chemical compound often associated with nootropics, skincare, and industrial applications.

Applications:
Pharmaceutical and Supplement Use:

Nootropic Effects: DMAE is marketed in dietary supplements for its potential to enhance cognitive function, memory, and mood. It is thought to work by increasing acetylcholine synthesis, a neurotransmitter important for brain activity.
Skin Care: DMAE is included in some anti-aging creams and cosmetics, where it is claimed to improve skin firmness and reduce fine lines.
Industrial Applications:

Intermediate in Synthesis: Used as a precursor in the production of resins, coatings, and polymers.
Corrosion Inhibitor: Used in water treatment and other industrial processes.
Research and Laboratory Use:

Common in chemical research as a reagent or intermediate.

Dimethylethanolamine (DMAE or DMEA) can be retained, and analyzed using a Primesep 100 mixed-mode stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water, acetonitrile (MeCN), and TFA as a buffer. Detection is carried out using ELSD

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN 40%
BufferAmmonium Formate pH 3.0 – 40 mM
Flow Rate1 ml/min
DetectionELSD, the nebulizer and evaporator temperatures 50°C,
with a gas flow rate of 1.6 Standard Liters per Minute (SLM)
LOD*10 ppm

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Class of CompoundsAmino alcohol
Analyzing CompoundsDimethylethanolamine (DMAE or DMEA)

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Dimethylethanolamine (DMAE or DMEA)
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.