Vecuronium bromide

Vecuronium bromide structural formula

CAS Number50700-72-6
Molecular FormulaC34H57BrN2O4
Molecular Weight637.745
InChI KeyVEPSYABRBFXYIB-PWXDFCLTSA-M
LogP3.23
Synonyms
  • Vecuronium bromide
  • (2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)-16-(1-methylpiperidin-1-ium-1-yl)-2-(piperidin-1-yl)androstane bromide
  • Androstane-3,17-diol, 16-(1-methyl-1-piperidiniumyl)-2-(1-piperidinyl)-, bromide, diacetate (ester), (2beta,3alpha,5alpha,16beta,17beta)- (1:1)
  • 50700-72-6
  • Piperidinium, 1-[(2?,3?,5?,16?,17?)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide
  • bromure de vecuronium
  • bromuro de vecuronio
  • Musculax
  • Norcuron
  • Piperidinium, 1-[(2?,3?,5?,16?,17?)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)
  • Vecuroniumbromid
  • 5alpha-Androstan-3alpha,17beta-diol, 16beta-pipecolinio-2beta-piperidino-,bromide,diacetate
  • EINECS 256-723-9
  • Vecuronii bromidum
  • UNII-7E4PHP5N1D
  • 1-(3alpha,17beta-Dihydroxy-2beta-piperidino-5alpha-androstan-16beta,5alpha-yl)-1-methylpiperidinium bromide, diacetate
  • 1-[3alpha,17beta-bis(acetoxy)-2beta-(1-piperidinyl)-5alpha-androstan-16beta-yl]-1-methylpiperidinium bromide
  • 63884-29-7
  • 72254-12-7
  • 74531-67-2

Applications:

Uv-Vis Spectrum of Vecuronium Bromide

March 5, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Vecuronium bromide check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Vecuronium bromide
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Determination of Vecuronium on Primesep SB Column

September 13, 2022

HPLC Method for Vecuronium bromide on Primesep SB by SIELC Technologies

HPLC Method for Determination of Vecuronium on Primesep SB Column

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Vecuronium bromide

Vecuronium bromide, also known as Norcuron, is a muscle relaxant with the chemical formula C34H57BrN2O4. It is primarily used during surgery and executions by lethal injection. Reversal of vecuronium’s effects can be achieved through administration sugammadex.

HPLC methods for Vecuronium bromide are of great interest to pharmaceutical research and industry. Vecuronium bromide can be separated and retained on a mixed-mode stationary phase Primesep SB column with embedded strong basic ion-pairing groups, using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and an Ammonium Formate (AmFm) ionic modifier. This analysis method can be UV detected at 260 nm with high resolution and peak symmetry and is compatible with Mass Spectrometry (MS), ELSD, and CAD.

Condition
Column Primesep SB, 2.1 x 100 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN – 10%
Buffer Ammonium Formate pH 3.0 – 50 mM, 100 mM
Flow Rate 0.2 ml/min
Detection ELSD, 50C

 

Description
Class of Compounds Drug
Analyzing Compounds Vecuronium bromide

Application Column

Primesep SB

Column Diameter: 2.1 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Vecuronium bromide
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Vecuronium bromide on Newcrom R1 HPLC column

February 16, 2018
Separation of Vecuronium bromide on Newcrom C18 HPLC column

Vecuronium bromide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Vecuronium bromide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.