Vecuronium bromide

Vecuronium bromide structural formula

CAS Number50700-72-6
Molecular FormulaC34H57BrN2O4
Molecular Weight637.745
InChI KeyVEPSYABRBFXYIB-PWXDFCLTSA-M
LogP3.23
Synonyms
  • Vecuronium bromide
  • (2beta,3alpha,5alpha,16beta,17beta)-3,17-Bis(acetyloxy)-16-(1-methylpiperidin-1-ium-1-yl)-2-(piperidin-1-yl)androstane bromide
  • Androstane-3,17-diol, 16-(1-methyl-1-piperidiniumyl)-2-(1-piperidinyl)-, bromide, diacetate (ester), (2beta,3alpha,5alpha,16beta,17beta)- (1:1)
  • 50700-72-6
  • Piperidinium, 1-[(2?,3?,5?,16?,17?)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide
  • bromure de vecuronium
  • bromuro de vecuronio
  • Musculax
  • Norcuron
  • Piperidinium, 1-[(2?,3?,5?,16?,17?)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methyl-, bromide (1:1)
  • Vecuroniumbromid
  • 5alpha-Androstan-3alpha,17beta-diol, 16beta-pipecolinio-2beta-piperidino-,bromide,diacetate
  • EINECS 256-723-9
  • Vecuronii bromidum
  • UNII-7E4PHP5N1D
  • 1-(3alpha,17beta-Dihydroxy-2beta-piperidino-5alpha-androstan-16beta,5alpha-yl)-1-methylpiperidinium bromide, diacetate
  • 1-[3alpha,17beta-bis(acetoxy)-2beta-(1-piperidinyl)-5alpha-androstan-16beta-yl]-1-methylpiperidinium bromide
  • 63884-29-7
  • 72254-12-7
  • 74531-67-2

Applications:

HPLC Method for Determination of Vecuronium on Primesep SB Column

September 13, 2022

Separation type: Liquid Chromatography Mixed-mode

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HPLC Method for Determination of Vecuronium on Primesep SB Column

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Vecuronium

Vecuronium bromide, also known as Norcuron, is a muscle relaxant used during surgery, intubation, and executions. HPLC methods for Vecuronium are of great interest to pharmaceutical research and industry. Vecuronium bromide can be separated and retained on a mixed-mode stationary phase Primesep SB column with embedded strong basic ion-pairing groups, using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and an Ammonium Formate (AmFm) ionic modifier. This analysis method can be UV detected at 260 nm with high resolution and peak symmetry and is compatible with Mass Spectrometry (MS), ELSD, and CAD.

Condition
Column Primesep SB, 2.1×100 mm, 5 µm, 100A
Mobile Phase MeCN – 10%
Buffer Ammonium Formate pH 3.0 – 50 mM, 100 mM
Flow Rate 0.2 ml/min
Detection ELSD, 50C

 

Description
Class of Compounds Drug
Analyzing Compounds Vecuronium

Application Column

Primesep SB

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

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Application Analytes:
Vecuronium bromide
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Vecuronium bromide on Newcrom R1 HPLC column

February 16, 2018
Separation of Vecuronium bromide on Newcrom C18 HPLC column

Vecuronium bromide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Vecuronium bromide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.