Vanillic acid

Vanillic acid structural formula

CAS Number121-34-6
Molecular FormulaC8H8O4
Molecular Weight168.148
InChI KeyWKOLLVMJNQIZCI-UHFFFAOYSA-N
LogP1.43
Synonyms
  • Vanillic acid
  • 4-Hydroxy-3-methoxybenzoic acid
  • Benzoic acid, 4-hydroxy-3-methoxy-
  • 121-34-6
  • Benzoic acid, 4-hydroxy-3-methoxy-
  • 2-Methoxy-4-carboxyphenol
  • 3-Methoxy-4-hydroxybenzoic acid
  • 4-Hydroxy-3-methoxybenzoic acid
  • Acide vanillique
  • acido vanilico
  • NSC 3987
  • NSC 674322
  • VANILLINSAEURE
  • Vanillinsaure
  • BRN 2208364
  • EINECS 204-466-8
  • VA (VAN)
  • UNII-GM8Q3JM2Y8
  • 3-Methoxy-4-hydroxybenzoate
  • 4-Hydroxy-3-methoxy-Benzoate
  • 4-Hydroxy-m-Anisate
  • 4-Hydroxy-m-Anisic acid
  • 4-hydroxy-3-methoxy-benzoic acid
  • Benzoic acid, 4-hydroxy-3-methoxy-
  • Protocatechuic acid 3-methyl ester
  • Protocatechuic acid, 3-methyl ester
  • Vanillate
  • m-Anisic acid, 4-hydroxy-
  • p-Vanillate
  • p-Vanillic acid

Applications:

Separation of Vanillic acid on Newcrom R1 HPLC column

February 16, 2018
Separation of Vanillic acid on Newcrom C18 HPLC column

Vanillic acid can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Vanillic acid
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.