Troger’s base

CAS Number529-81-7
Molecular FormulaC17H18N2
Molecular Weight250.34
InChI KeySXPSZIHEWFTLEQ-UHFFFAOYSA-N
LogP3.8
Synonyms
  • Tröger's base
  • Troeger's base
  • 529-81-7
  • 2,8-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  • SP9UUR2HG4
  • NSC-68211
  • 2,8-Dimethyl-6H,12H-5,11-methanodibenzo(b,f)(1,5)diazocine
  • 6H,12H-5,11-Methanodibenzo(b,f)(1,5)diazocine, 2,8-dimethyl-
  • DTXSID30200950
  • 2,8-dimethyl-6H,12H-5,11-methanodibenzo(b,f)(1,5)-diazocine
  • 6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine, 2,8-dimethyl-
  • Troger base
  • RefChem:900656
  • DTXCID60123441
  • Troger's base
  • 14645-24-0
  • (-)-TROGER'S BASE
  • 21451-74-1
  • (+)-Troger's base
  • (-)-TROGER/'S BASE
  • 5,13-dimethyl-1,9-diazatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10(15),11,13-hexaene
  • NSC 68211
  • 6H,11-Methanodibenzo[b,f](1,5)diazocine, 2,8-dimethyl-
  • 6H,11-Methanodibenzo[b,f][1,5]diazocine, 2,8-dimethyl-
  • Troger'S
  • Tr ger's base
  • (5S,11S)-(+)-2,8-Dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  • Ethano-Troger's base
  • (+/-)-Troeger base
  • Troger's Base, 98%
  • UNII-SP9UUR2HG4
  • (+/-)-Troeger's base
  • (-)-Tr ouml ger's base
  • Oprea1_285718
  • CBDivE_011389
  • MLS000105151
  • SCHEMBL2759894
  • CHEMBL1303327
  • SCHEMBL29409666
  • SXPSZIHEWFTLEQ-UHFFFAOYSA-N
  • HMS1579O10
  • HMS2376O17
  • AAA52981
  • NSC68211
  • CCG-15765
  • MFCD00134397
  • STK029423
  • (5R,11R)-2,8-Dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  • (5S,11S)-2,8-Dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  • AKOS000613560
  • 72151-03-2
  • SMR000055080
  • DB-042847
  • DB-066514
  • CS-0376657
  • ST50411744
  • 2,12H-5,11-methanodibenzo[b,f](1,5)diazocine
  • AG-205/06529009
  • EN300-18225157
  • Q410493
  • SR-01000408172
  • WLN: T C66 K66 A BN JN&T&TJ F1 N1
  • SR-01000408172-1
  • BRD-K21537419-001-07-1
  • (+)-Tr??ger's base, for chiral derivatization, >=99.0%
  • (-)-Tr??ger's base, for chiral derivatization, >=99.0%
  • ( )-2,8-Dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine
  • 2,8-Dimethyl-6,12-dihydro-5,11-methanodibenzo[b,f][1,5]diazocine
  • 2,8-Dimethyl-6H,12H-5,11-methano-dibenzo[b,f][1,5]diazocine
  • 5,11-methano-2,8-dimethyl-5,6,11,12-tetrahydrodibenzo[b,f][1,5]diazocine
  • 5,13-dimethyl-1,9-diazatetracyclo[7.7.1.0<2,7>.0<10,15>]heptadeca-2(7),3,5,10( 15),11,13-hexaene
  • 5,13-dimethyl-1,9-diazatetracyclo[7.7.1.0^{2,7}.0^{10,15}]heptadeca-2,4,6,10,12,14-hexaene
  • 5,13-dimethyl-1,9-diazatetracyclo[7.7.1.0~2,7~.0~10,15~]heptadeca-2,4,6,10,12,14-hexaene
  • InChI=1/C17H18N2/c1-12-3-5-16-14(7-12)9-18-11-19(16)10-15-8-13(2)4-6-17(15)18/h3-8H,9-11H2,1-2H

Applications:

HPLC Method for Analysis of Troger’s Base on Primesep 200  Column

June 23, 2026

HPLC Method for Analysis of Troger's base on Primesep 200 Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Troger's base.

Troger’s base, also written as Tröger’s base, is a tetracyclic organic compound with the chemical formula C17H18N2. The correct structure for the compound was a mystery for 48 years after it’s initial synthesis by Julius Tröger. You can find detailed UV spectra of Troger's base and information about its various lambda maxima by visiting the following link.

Troger's base can be retained and analyzed using the Primesep 200 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using LC MS.

Condition

ColumnPrimesep 200, 4.6 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 30/70%
BufferH2SO4  – 0.1%
Flow Rate1.0 ml/min
DetectionUV 200
Limit Of Detection*80 ppb
*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Description

Class of CompoundsOrganic Acid
Analyzing CompoundsTroger's base

Application Column

Primesep 200

Column Diameter: 4.6 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Troger’s base
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Chiral Separation of Troger’s Base on Cyralis CM Column

June 17, 2026

HPLC Method for Analysis of Troger's base on Cyralis CM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Troger's base.

Troger’s base, also written as Tröger’s base, is a tetracyclic organic compound with the chemical formula C17H18N2. The correct structure for the compound was a mystery for 48 years after it’s initial synthesis by Julius Tröger. You can find detailed UV spectra of Troger's base and information about its various lambda maxima by visiting the following link.

This application describes a normal-phase chiral HPLC method for the separation of Troger's base enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.

Troger's base can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, IPA, and DEA. Detection is performed using UV.

Condition

ColumnCyralis CM, 4.6 x 250 mm, 5 µm, 100 A, dual ended
Mobile PhaseHexane/IPA/DEA- 90/10/0.5%
Flow Rate1.0 mL/min
DetectionUV 230 nm
Resolution2.19

Description

Class of CompoundsOrganic Compound
Analyzing CompoundsTroger's base

Application Column

Cyralis CM

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Troger’s base
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Uv-Vis Spectrum of Troger’s base

April 10, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Troger's base check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. This analysis was done with the mobile phase made of 20% acetonitrile and 80% water.

 

 

 

 

Application Analytes:
Troger’s base
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.