| CAS Number | 521-78-8 |
|---|---|
| Molecular Formula | C24H30N2O4 |
| Molecular Weight | 410.515 |
| InChI Key | YDGHCKHAXOUQOS-BTJKTKAUSA-N |
| LogP | 4.80 |
| Synonyms |
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Applications:
HPLC Chiral Separation of Trimipramine Enantiomers on Cyralis CM Column
August 11, 2026
HPLC Chiral Method for Analysis of Trimipramine, Trimipramine maleate Enantiomers on Cyralis CM Column by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Trimipramine, Trimipramine maleate.
Trimipramine is a tricyclic antidepressant (TCA) with the chemical formula C20H26N2. It is used primarily used to treat depression, but it has also been used to treat insomnia, anxiety disorders, and psychosis due to it’s sedative, anxiolytic, and antipsychotic effects. Unlike other TCAs, it is a weaker monoamine reuptake inhibitor. You can find detailed UV spectra of Trimipramine, Trimipramine maleate and information about its various lambda maxima by visiting the following link.
This application describes a normal-phase chiral HPLC method for the separation of Trimipramine, Trimipramine maleate enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications. For best results, the sample should be prepared fresh for analysis.
Trimipramine, Trimipramine maleate can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of sodium perchlorate and acetonitrile. Detection is performed using UV.
Condition
| Column | Cyralis CM, 4.6 x 250 mm, 5 µm, 100 A, reversed phase |
| Mobile Phase | NaClO4/MeCN |
| Flow Rate | 1.0 mL/min |
| Detection | UV 220 nm |
| Resolution | 1.51 |
Description
| Class of Compounds | Drug |
| Analyzing Compounds | Trimipramine, Trimipramine maleate |
Application Column
Cyralis CM
Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: reversed phase
Trimipramine maleate
HPLC Method for Analysis of Trimipramine
May 6, 2016
Trimipramine is a tricyclic antidepressant with antihistamine and sedative properties. It acts by decreasing the reuptake of norepinephrine and serotonin (5-HT), which is why it is used as treatment of major depressive disorder. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Trimipramine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
Application Column
Primesep 200
The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.
Select optionsTrimipramine maleate
HPLC Retention of Trimipramine on Primesep C
November 21, 2006
Trimipramine is a tricyclic antidepressant with antihistamine and sedative properties. It acts by decreasing the reuptake of norepinephrine and serotonin (5-HT), which is why it is used as treatment of major depressive disorder. Primesep 200, a reverse phase column, contains embedded acidic ionizable groups and can retain Trimipramine. The method is UV compatible and can be used as a general approach for analyzing similar compounds.
Application Column
Primesep C
Column Diameter: 3.2 mm
Column Length: 50 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Trimipramine maleate
