Nifedipine

Nifedipine structural formula

CAS Number21829-25-4
Molecular FormulaC17H18N2O6
Molecular Weight346.339
InChI KeyHYIMSNHJOBLJNT-UHFFFAOYSA-N
LogP2.20
Synonyms
  • Nifedipine
  • Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
  • 21829-25-4
  • 5-22-04-00268
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
  • 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
  • 2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine
  • 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3,5-dimethyl ester
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-, dimethyl ester
  • 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
  • 4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
  • Adalat CC
  • Adalat CR
  • Adalat Crono
  • Adalat FT
  • Adalat GITS
  • Adalat GITS 30
  • Adalat LA
  • Adalat LP
  • Adalat Oros
  • Adalat PA
  • Adalat retard
  • Adalate
  • Adapine
  • Adapress
  • Aldipin
  • Alfadat
  • Alonix S
  • Alpha-Nifedipine Retard
  • Angipec
  • Apo-Nifed
  • Aprical
  • Calcibloc
  • Calcigard
  • Calciguard
  • Calcilat
  • Cardifen
  • Cardilat
  • Cardionorm
  • Chronadalate
  • Chronadalate LP
  • Citilat
  • Coracten
  • Cordafen
  • Cordaflex
  • Cordalat
  • Cordicant
  • Cordilan
  • Cordipin
  • Corinfar
  • Corotrend
  • Corynphar
  • Dignokonstant
  • Dilafed
  • Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
  • Dimethyl 4-(o-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
  • Dipinkor
  • Duranifin
  • Ecodipi
  • Ecodipin
  • Ecodipin E
  • Fedcor Retard
  • Fedipin
  • Fenamon
  • Fenamon SR
  • Fenihidine
  • Hadipine
  • Hexadilat
  • Introcar
  • Kordafen
  • Macorel
  • Megalat
  • Myogard
  • Nedipin
  • Nicardia
  • Nicardia retard
  • Nifangin
  • Nifdemin
  • Nifebene
  • Nifecard
  • Nifecor
  • Nifedate
  • Nifedepat
  • Nifedicor
  • NIfedilat
  • Nifedin
  • Nifedine
  • Nifedipin
  • Nifedipine retard
  • nifedipino
  • Nifedipres
  • Nifedirex LP
  • Nifelan
  • Nifelantern
  • Nifelat
  • Nifelat Q
  • Nifelate
  • Nifensar XL
  • Nificard
  • Nifidine
  • Nifipen
  • Niphedipine
  • Normadil
  • Novo Nifedin
  • Nyefax Retard
  • Osmo-Adalat
  • Pidilat
  • Procardia
  • Procardia XL
  • Sepamit
  • Sepamit R
  • Slofedipine XL
  • Tensopin
  • Tibricol
  • UV-ENP 349PINA
  • Vasdalat
  • Vasdalat Retard
  • Vasofed
  • Zenusin
  • BRN 0497773
  • Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-3,5-pyridinedicarboxylate
  • EINECS 244-598-3
  • Fenihidin
  • Nifediac
  • Afeditab
  • Afeditab CR
  • Nifedical
  • Nifedical XL
  • Adipine XL
  • 4-(2'-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
  • Nifedipinum
  • UNII-I9ZF7L6G2L
  • 101539-70-2
  • 101554-38-5
  • 11104-22-6

Applications:

Separation of Nifedipine on Newcrom R1 HPLC column

February 16, 2018
Separation of Nifedipine on Newcrom C18 HPLC column

Nifedipine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Nifedipine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.