Meclizine

Meclizine structural formula

UV Spectra of Meclizine

CAS Number569-65-3
Molecular FormulaC25H27ClN2
Molecular Weight390.960
InChI KeyOCJYIGYOJCODJL-UHFFFAOYSA-N
LogP4.64
Synonyms
  • Meclizine
  • 1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
  • 569-65-3
  • Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-
  • (.+-.)-Meclizine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)diethylenediamine
  • 1-(p-Chlorobenzhydryl)-4-(m-methylbenzyl)piperazine
  • 1-(p-Chlorobenzohydryl)-4-(m-methylbenzyl) piperazine
  • 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl) piperazine
  • 1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • Ancolan
  • Histametizyne
  • Meclozin
  • meclozina
  • Meclozine
  • Navicalm
  • Neo-Istafene
  • NSC 169189
  • Parachloramine
  • Piperazine, 1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)-
  • Postafene
  • Ravelon
  • Suprimal
  • U.C.B. 5062
  • Vomisseis
  • Bonadettes
  • BRN 0332002
  • Calmonal
  • Chiclida
  • 1-p-Chlorobenzhydryl-4-m-methylbenzylpiperazine
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine
  • 1-((4-Chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)piperazine
  • EINECS 209-323-3
  • Histamethine
  • Histamethizine
  • Histametizine
  • Itinerol
  • Monamine
  • Neo-suprimal
  • Neo-suprimel
  • Peremesin
  • Sea-Legs
  • Siguran
  • Travelon
  • (+-)-Meclizine
  • Dramamine II
  • Meclozinum
  • UNII-3L5TQ84570

Applications:

HPLC Method for Analysis of Meclizine on Primesep B Column

July 30, 2018

HPLC Method for Meclizine on Primesep B by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Meclizine 

Meclizine is a histamine H1 antagonist and a synthetic piperazine. It is used to prevent and treat motion sickness, vertigo, and nausea during pregnancy. The side effects that may occur include drowsiness, dry mouth, and tiredness. The method is UV compatible and can be used as a general approach for analyzing similar compounds.

Meclizine can be retained and analyzed using the Primesep B stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric buffer. Detection is performed using UV.

Condition
Column Primesep B, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 10/90%
Buffer H3PO4 – 0.2 %
Flow Rate 1.0 ml/min
Detection UV, 232 nm

Description
Class of Compounds
 Drug, Antihistamine, Hydrophobic
Analyzing Compounds Meclizine

Application Column

Primesep B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Meclizine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.