Mannitol

CAS Number87-78-5
Molecular FormulaC6H14O6
Molecular Weight182.17
InChI KeyFBPFZTCFMRRESA-KVTDHHQDSA-N
LogP-3.1
Synonyms
  • D-mannitol
  • mannitol
  • 69-65-8
  • Mannite
  • Osmitrol
  • Manna sugar
  • Cordycepic acid
  • Resectisol
  • Diosmol
  • Mannit
  • D-(-)-Mannitol
  • Mannazucker
  • Mannidex
  • Mannigen
  • Mannistol
  • Invenex
  • Isotol
  • Osmosal
  • Mannitol, D-
  • Marine Crystal
  • Maniton-S
  • Mannogem 2080
  • Bronchitol
  • (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
  • (2R,3R,4R,5R)-hexane-1,2,3,4,5,6-hexol
  • Mannitol 5%
  • Aridol
  • Mannitol 10%
  • Mannitol 15%
  • Mannitol 20%
  • Osmitrol 5% In Water
  • Osmitrol 10% In Water
  • Osmitrol 15% In Water
  • Osmitrol 20% In Water
  • MANNITOL 25%
  • Resectisol In Plastic Container
  • Mannitol (USP)
  • Mannitol 5% In Plastic Container
  • NCI-C50362
  • Mannitol 10% In Plastic Container
  • Mannitol 15% In Plastic Container
  • Mannitol 20% In Plastic Container
  • Mannitolum
  • CHEBI:16899
  • Mannitol [USP]
  • 3OWL53L36A
  • INS NO.421
  • OSMITROL 5% IN WATER IN PLASTIC CONTAINER
  • DTXSID1023235
  • OSMITROL 10% IN WATER IN PLASTIC CONTAINER
  • OSMITROL 15% IN WATER IN PLASTIC CONTAINER
  • OSMITROL 20% IN WATER IN PLASTIC CONTAINER
  • INS-421
  • MANNITOL 10% W/ DEXTROSE 5% IN DISTILLED WATER
  • E-421
  • NSC-407017
  • E421
  • DTXCID603235
  • MANNITOL 5% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.12%
  • MANNITOL 15% W/ DEXTROSE 5% IN SODIUM CHLORIDE 0.45%
  • manita
  • NSC407017
  • ARIDOL KIT
  • GlyTouCan:G51661YR
  • GD11 Rx SCM C5
  • CHEBI:29864
  • CURESTEM CELL HEALER C20
  • Aridol Bronchial Challenge Test Kit
  • G51661YR
  • 200-711-8
  • 201-770-2
  • DL-Mannitol
  • Osmofundin
  • 87-78-5
  • Mannitol (VAN)
  • D-Mannit
  • Hexahydroxyhexane
  • MFCD00064287
  • Mannitol;Mannite
  • BRN 1721898
  • 133-43-7
  • mannitol-d
  • rel-(2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexaol
  • Mannitol [USAN]
  • NCGC00164246-01
  • Mannidex 16700
  • MTL
  • CAS-69-65-8
  • Osmitrol (TN)
  • SMR000857324
  • CCRIS 369
  • D-Mannitol - EP
  • HSDB 714
  • SR-01000838849
  • D-Mannitol, EP, USP grade
  • NSC 9256
  • EINECS 200-711-8
  • EINECS 201-770-2
  • NSC 407017
  • UNII-3OWL53L36A
  • Cordycepate
  • Manitol
  • D-mitobronitol
  • AI3-19511
  • Maniton s
  • Mannit p
  • D-?Mannitol
  • Bronchitol (TN)
  • (D)-mannitol
  • Mannitol 25
  • Mannitol 35
  • Mannitol 60
  • D(-)Mannitol
  • Pearlitol 25 c
  • Pearlitol 50 c
  • Mannitol m300
  • Pearlitol 160 c
  • Mannitol 200
  • Mannitol 300
  • Pearlitol 200 sd
  • Pearlitol 300 dc
  • Mannitol 2080
  • D-Mannit 1000 microg/mL in Methanol
  • D-Mannitol (Osmitrol)
  • D-Mannitol (JP18)
  • MANNITOL [HSDB]
  • MANNITOL [FCC]
  • Crystalline mannitol fine
  • MANNITOL [II]
  • MANNITOL [MI]
  • CCFD200109Mannitol
  • MANNITOL [VANDF]
  • D-Mannitol, ACS reagent
  • D-Mannitol, >=98%
  • M0044
  • D-MANNITOL [JAN]
  • MANNITOL [MART.]
  • SCHEMBL919
  • bmse000099
  • CHEMBL689
  • Epitope ID:114705
  • MANNITOL [USP-RS]
  • MANNITOL [WHO-DD]
  • Isomalt impurity, mannitol-
  • Crystalline mannitol standard
  • D-MANNITOL [WHO-IP]
  • 4-01-00-02841 (Beilstein Handbook Reference)
  • ED1D1E61-FEFB-430A-AFDC-D1F4A957FC3D
  • MLS001335977
  • MLS001335978
  • D-Mannitol, Biochemical grade
  • Crystalline mannitol extra-fine
  • MANNITOL [EP IMPURITY]
  • MANNITOL [ORANGE BOOK]
  • D-Mannitol, AR, >=99%
  • D-Mannitol, LR, >=99%
  • orb1302416
  • orb1310638
  • MANNITOL [EP MONOGRAPH]
  • MANNITOL [USP MONOGRAPH]
  • SCHEMBL19304988
  • DTXSID30858955
  • MSK3101
  • MANNITOLUM [WHO-IP LATIN]
  • HMS2230N11
  • HY-N0378
  • Tox21_112092
  • Tox21_201487
  • Tox21_300483
  • AKOS006280947
  • D-Mannitol, plant cell culture tested
  • Tox21_112092_1
  • BCP9000575
  • CCG-266445
  • D-Mannitol, BioXtra, >=98% (GC)
  • DB00742
  • MM02190
  • MM63310
  • D-Mannitol, NIST(R) SRM(R) 920
  • ISOMALT IMPURITY B [EP IMPURITY]
  • NCGC00164246-03
  • NCGC00164246-04
  • NCGC00164246-05
  • NCGC00164246-18
  • NCGC00254277-01
  • NCGC00259038-01
  • 85085-15-0
  • AC-12776
  • AC-14054
  • AS-30501
  • D-Mannitol, tested according to Ph.Eur.
  • DA-65240
  • D-Mannitol, p.a., 96.0-101.5%
  • D-Mannitol, SAJ first grade, >=99.0%
  • SORBITOL-MANNITOL COMPONENT MANNITOL
  • D-Mannitol, SAJ special grade, >=99.0%
  • E 421
  • NS00068035
  • S2381
  • SW220287-1
  • C00392
  • D00062
  • EN300-212188
  • AB00443917_06
  • ISOMALT IMPURITY, MANNITOL- [USP IMPURITY]
  • Q407646
  • SR-01000838849-3
  • SR-01000838849-4
  • BRD-K30374899-001-09-3
  • D-Mannitol, ACS reagent, for microbiology, >=99.0%
  • LACTITOL MONOHYDRATE IMPURITY C [EP IMPURITY]
  • D-Mannitol, meets EP, FCC, USP testing specifications
  • Mannitol, European Pharmacopoeia (EP) Reference Standard
  • Z1198149813
  • D-Mannitol, BioUltra, >=99.0% (sum of enantiomers, HPLC)
  • Mannitol, United States Pharmacopeia (USP) Reference Standard
  • D-Mannitol, >=99.9999% (metals basis), for boron determination
  • Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material

Applications:

HPLC Method for Analysis of Sucralose, Mannitol, and Lactulose on Primesep S2 Column Using Mass Spectrometry

August 13, 2025

HPLC Method for Sucralose, Mannitol, Lactulose on Primesep S2 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Sucralose, Mannitol, Lactulose

Sucralose is an synthetic organochlorine compound with the molecular formula C12H19Cl3O8.

Properties:
Appearance: Typically a white, odorless, crystalline powder.

Molecular weight: ~397.6 g/mol

Solubility: Soluble in water.

Uses: An artificial sweetener used to provide sweetness in food and beverages without the calories of sugar. 

Mannitol is an organic compound with the molecular formula C6H14O6.

Properties:
Appearance: Typically a white, odorless, crystalline powder or granules.

Molecular weight: ~182.17 g/mol

Solubility: Soluble in water.

Uses: A versatile medication with various uses in healthcare, primarily as an osmotic diuretic. 

Lactulose is an synthetic disaccharide with the molecular formula C12H22O11.

Properties:
Appearance: Typically a white, odorless crystalline powder with a sweet taste.

Molecular weight: ~342.30 g/mol

Solubility: Soluble in water.

Uses: Used for treating constipation and hepatic encephalopathy (HE). 

Sucralose, Mannitol, Lactulose can be retained and analyzed using the Primesep S2 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and formic acid acid. Detection is performed using MS.

ColumnPrimesep S2, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN – 85%
BufferFormic Acid – 0.2%
Flow Rate0.5 ml/min
DetectionMS ESI –

Class of CompoundsSugar
Analyzing CompoundsSucralose, Mannitol, Lactulose

Application Column

Primesep S2

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Lactulose
Mannitol
Sucralose
Application Detection:
LC MS Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Sucralose, Mannitol, and Lactulose on Primesep S2 Column Using ELSD

August 13, 2025

HPLC Method for Sucralose, Mannitol, Lactulose on Primesep S2 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Sucralose, Mannitol, Lactulose

Sucralose is an synthetic organochlorine compound with the molecular formula C12H19Cl3O8.

Properties:
Appearance: Typically a white, odorless, crystalline powder.

Molecular weight: ~397.6 g/mol

Solubility: Soluble in water.

Uses: An artificial sweetener used to provide sweetness in food and beverages without the calories of sugar. 

Mannitol is an organic compound with the molecular formula C6H14O6.

Properties:
Appearance: Typically a white, odorless, crystalline powder or granules.

Molecular weight: ~182.17 g/mol

Solubility: Soluble in water.

Uses: A versatile medication with various uses in healthcare, primarily as an osmotic diuretic. 

Lactulose is an synthetic disaccharide with the molecular formula C12H22O11.

Properties:
Appearance: Typically a white, odorless crystalline powder with a sweet taste.

Molecular weight: ~342.30 g/mol

Solubility: Soluble in water.

Uses: Used for treating constipation and hepatic encephalopathy (HE). 

Sucralose, Mannitol, Lactulose can be retained and analyzed using the Primesep S2 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and formic acid acid. Detection is performed using ELSD.

ColumnPrimesep S2, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN – 85%
BufferFormic Acid – 0.2%
Flow Rate1.0 ml/min
DetectionELSD
Class of CompoundsSugar
Analyzing CompoundsSucralose, Mannitol, Lactulose

Application Column

Primesep S2

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Lactulose
Mannitol
Sucralose
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Mannitol on Primesep S2 Column

August 11, 2025

HPLC Method for Mannitol on Primesep S2 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Mannitol

Mannitol is an organic compound with the molecular formula C6H14O6.

Properties:
Appearance: Typically a white, odorless, crystalline powder or granules.

Molecular weight: ~182.17 g/mol

Solubility: Soluble in water.

Uses: A versatile medication with various uses in healthcare, primarily as an osmotic diuretic. 

Mannitol can be retained and analyzed using the Primesep S2 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and formic acid. Detection is performed using ELSD.

ColumnPrimesep S2, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN – 85%
BufferFormic Acid – 0.2%
Flow Rate1.0 ml/min
DetectionELSD
LOD4.380 ppm

Class of CompoundsSugar Alcohol
Analyzing CompoundsMannitol

Application Column

Primesep S2

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Mannitol
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.