HPLC Method for Analysis of Ropinirole in Pharmaceutical Formulation on Primesep 100 Column

HPLC Method for Analysis of Ropinirole on Primesep 100 Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Ropinirole.

Ropinirole is an drug with the chemical formula C16H24N2O. It is primarily used to treat Parkinson’s disease and restless leg syndrome. It works as a D2, D3, and D4 dopamine receptor agonist. You can find detailed UV spectra of Ropinirole and information about its various lambda maxima by visiting the following link.

Ropinirole can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV.

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 60/40
BufferH2SO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 195 nm
Limit Of Detection*3 ppb
*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Description

Class of CompoundsDrug
Analyzing CompoundsRopinirole

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Ropinirole
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.