HPLC Method for Analysis of 2-Deoxy-D-Glucose on Primesep S2 Column

HPLC Method for 2-Deoxy-D-Glucose on Primesep S2 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of 2-Deoxy-D-Glucose

2-Deoxy-D-Glucose is an organic compound with the molecular formula C6H12O5.

Properties:
Appearance: Typically a white to cream-colored powder or crystalline powder.

Molecular weight: ~164.16 g/mol

Solubility: Soluble in water.

Uses:  Being investigated as an anti-cancer agent, an antiviral treatment, and an anticonvulsant, and it has shown promise in reducing oxygen dependence in COVID-19 patients. 

2-Deoxy-D-Glucose can be retained and analyzed using the Primesep S2 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and formic acid. Detection is performed using ELSD.

ColumnPrimesep S2, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN – 95%
BufferFormic Acid – 0.1%
Flow Rate1.0 ml/min
DetectionELSD
LOD3.25 ppm

Class of CompoundsDeoxy Sugar
Analyzing Compounds2-Deoxy-D-Glucose

Application Column

Primesep S2

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
2-Deoxy-D-Glucose
Application Detection:
ELSD Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.