Estetrol

Skeletal formula of estetrol

CAS Number15183-37-6
Molecular FormulaC18H24O4
Molecular Weight304.4
InChI KeyAJIPIJNNOJSSQC-NYLIRDPKSA-N
LogP1.5
Synonyms
  • ESTETROL
  • 15183-37-6
  • Estetrol anhydrous
  • 15alpha-hydroxyestriol
  • estetrolum
  • oestetrol
  • ENB39R14VF
  • Estetrol (anhydrous)
  • 15 alpha-hydroxyestriol
  • CHEBI:142773
  • DTXSID50164888
  • estra-1,3,5(10)-triene-3,15alpha,16alpha,17beta-tetrol
  • Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15alpha,16alpha,17beta)-
  • 15 alpha Hydroxyestriol
  • RefChem:591228
  • 15 alpha Hydroxy Estriol
  • 15-alpha-Hydroxy-Estriol
  • DTXCID4087379
  • (1S,10R,11S,12R,13R,14R,15S)-15-methyltetracyclo(8.7.0.02,?.011,1?)heptadeca-2,4,6-triene-5,12,13,14-tetrol
  • (8R,9S,13S,14S,15R,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,15,16,17-tetrol
  • estetrol monohydrate
  • 15.alpha.-hydroxyestriol
  • ESTETROL (E4)
  • E4
  • Estetrol (USAN)
  • Estetrol [USAN]
  • (8R,9S,13S,14S,15R,16R,17R)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,15,16,17-tetraol
  • (14beta,15alpha,16alpha,17alpha)-Estra-1,3,5(10)-Triene-3,15,16,17-Tetrol
  • E-4
  • UNII-ENB39R14VF
  • estell
  • Donesta
  • Estetrol (hydrous)
  • ESTETROL [INN]
  • ESTETROL [WHO-DD]
  • MLS006010253
  • SCHEMBL145580
  • orb1707327
  • Estetrol, >=98% (HPLC)
  • CHEMBL1230314
  • SCHEMBL29424342
  • GTPL11591
  • AJIPIJNNOJSSQC-NYLIRDPKSA-N
  • BDBM158505
  • GLXC-21863
  • EX-A7107
  • ESTETROL (ANHYDROUS) [USAN]
  • WHO 10439
  • AKOS030254521
  • AT27982
  • DB12235
  • FE22814
  • NCGC00345819-03
  • DA-53011
  • HY-15731
  • SMR004701329
  • US9034854, E4
  • CS-0008552
  • NS00070000
  • C22548
  • D11513
  • Q5401078
  • BRD-K75445017-001-01-1
  • Drovelis (EMA); ; estetrol monohydrate + drospirenone
  • Lydisilka (EMA); ; estetrol monohydrate + drospirenone
  • Nextstellis (US); estetrol monohydrate + drospirenone
  • estra-1(10),2,4-triene-3,15alpha,16alpha,17beta-tetrol
  • 3,15alpha,16alpha,17beta-tetrahydroxyestra-1,3,5(10)-triene
  • Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol
  • (15alpha,16alpha,17beta)-estra-1(10),2,4-triene-3,15,16,17-tetrol
  • ESTRA-1,3,5(10)-TRIENE-3,15.ALPHA.,16.ALPHA.,17.BETA.-TETROL
  • ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL, (15.ALPHA.,16.ALPHA.,17.BETA.)-
  • (15?,16?,17?)-Estra-1,3,5(10)-triene-3,15,16,17-tetrol;Estra-1,3,5(10)-triene-3,15?,16?,17?-tetrol;15?-Hydroxyestriol
  • 16127-99-4
  • 4OH

Applications:

Uv-Vis Spectrum of Estetrol

February 17, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Estetrol check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Estetrol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Estetrol, Estiol, Estrone, and Besta-Estradiol Without Buffer on Chromni Column

September 16, 2025

HPLC Method for Estrone, Estradiol, Estriol, Estetrol on Chromni by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Estrone, Estradiol, Estriol, Estetrol

Estetrol is an estrogenic steroid hormone compound with the molecular formula C18H24O4.

Properties:
Appearance: Typically a white, odorless, powder.

Molecular weight: ~270.4 g/mol

Solubility: Soluble in water.

Uses: Production of contraceptives.

Estriol is an estrogenic steroid hormone compound with the molecular formula C18H24O3.

Properties:
Appearance: Typically a white, odorless, powder.

Molecular weight: ~288.4 g/mol

Solubility: Soluble in benzene, water, alcohol, and vegetable oils.

Uses: Hormone Replacement Therapy and similar medication.

Estrone is an synthetic estrogenic steroid hormone with the molecular formula C18H22O2.

Properties:
Appearance: Typically a white, odorless, crystals.

Molecular weight: ~270.4 g/mol

Solubility: Soluble in benzene, water, acetone, and vegetable oils.

Uses: Production of medication

Beta-Estradiol is an estrogenic steroid hormone compound with the molecular formula C18H24O2.

Properties:
Appearance: Typically a white, odorless, crystals.

Molecular weight: ~272.4 g/mol

Solubility: Soluble in ethanol, water, and vegetable oils.

Uses: Production of medication for treatment of menopausal symptoms

Estrone, Estradiol, Estriol, Estetrol can be retained and analyzed using the Chromni stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN). Detection is performed using UV.

ColumnChromni, 4.6 x 150 mm, 3 µm, 100 A, dual ended
Mobile PhaseMeCN – 90%
BufferNone
Flow Rate1.0 ml/min
DetectionUV 280 nm

Class of CompoundsEstrogen
Analyzing CompoundsEstrone, Estradiol, Estriol, Estetrol

Application Column

Chromni

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Estetrol
Estradiol
Estriol
Estrone
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Estetrol, Estiol, Estrone, and Besta-Estradiol on Chromni Column

September 16, 2025

HPLC Method for Estrone, Estradiol, Estetrol, Estriol on Chromni by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Estrone, Estradiol, Estetrol, Estriol

Estetrol is an synthetic organochlorine compound with the molecular formula C18H24O4.

Properties:
Appearance: Typically a white, odorless, powder.

Molecular weight: ~270.4 g/mol

Solubility: Soluble in water.

Uses: Production of contraceptives.

Estriol is an synthetic organochlorine compound with the molecular formula C18H24O3.

Properties:
Appearance: Typically a white, odorless, powder.

Molecular weight: ~288.4 g/mol

Solubility: Soluble in benzene, water, alcohol, and vegetable oils.

Uses: Hormone Replacement Therapy and similar medication.

Estrone is an synthetic organochlorine compound with the molecular formula C18H22O2.

Properties:
Appearance: Typically a white, odorless, crystals.

Molecular weight: ~270.4 g/mol

Solubility: Soluble in benzene, water, acetone, and vegetable oils.

Uses: Production of medication

Beta-Estradiol is an synthetic organochlorine compound with the molecular formula C18H24O2.

Properties:
Appearance: Typically a white, odorless, crystals.

Molecular weight: ~272.4 g/mol

Solubility: Soluble in ethanol, water, and vegetable oils.

Uses: Production of medication for treatment of menopausal symptoms

Estrone, Estradiol, Estetrol, Estriol can be retained and analyzed using the Chromni stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and ammonium formate. Detection is performed using UV.

ColumnChromni, 4.6 x 150 mm, 3 µm, 100 A, dual ended
Mobile PhaseMeCN – 20%
BufferAmmonium Formate – 10mM
Flow Rate1.0 ml/min
DetectionUV 280 nm

Class of CompoundsEstrogen
Analyzing CompoundsEstrone, Estradiol, Estetrol, Estriol

Application Column

Chromni

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Estetrol
Estradiol
Estriol
Estrone
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.