Cyclosporin C

CAS Number59787-61-0
Molecular FormulaC62H111N11O13
Molecular Weight1218.6
InChI KeyJTOKYIBTLUQVQV-QRVTZXGZSA-N
LogP6.9
Synonyms
  • Cyclosporin C
  • 59787-61-0
  • 7-Threonine-cyclosporin A
  • 6S744L5508
  • DTXSID501017530
  • RefChem:129977
  • DTXCID401475719
  • Thr2-cyclosporine
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • C62H111N11O13
  • Cyclosporin C (>80%)
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-30-((R)-1-hydroxyethyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotri-triacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • UNII-6S744L5508
  • [Thr2]CsA
  • CYCLOSPORIN C [MI]
  • orb1306794
  • CHEMBL2370014
  • SCHEMBL22032784
  • CHEBI:218755
  • GLXC-05655
  • EX-A2529
  • HY-N6027
  • HB3859
  • AKOS037748855
  • CYCLOSPORIN A, 7-L-THREONINE-
  • EBC-615826
  • FC20755
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-30-[(1R)-1-hydroxyethyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
  • BS-17695
  • CS-0032194
  • Cyclosporin C(Discontinued,See C4X-19986)
  • D83121
  • 787C610
  • SR-01000872584
  • SR-01000872584-1
  • Q27265421
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-Hydroxyethyl]-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(1R)-1-hydroxyethyl]-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
  • CYCLO(L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-L-VALYL-(3R,4R,6E)-6,7-DIDEHYDRO-3-HYDROXY-N,4-DIMETHYL-L-2-AMINOOCTANOYL-L-THREONYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL)
  • Cyclo[[(E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl]-L-threonine-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl]

Applications:

HPLC MS Method for Separation of Cyclosporin A, B and C on Primesep 200 Column

September 8, 2026

HPLC Method for Analysis of Cyclosporin A, Cyclosporin B, Cyclosporin C on Primesep 200 by SIELC Technologies

HPLC Method for Analysis of Cyclosporin A, Cyclosporin B, Cyclosporin C in on Primesep 200 Column

Cyclosporine A, also known as cyclosporin and ciclosporin, is a calcineurin inhibitor with the molecular formula C62H111N11O12. It is used primarily as a an immunosuppressant medication to treat rheumatoid arthritis, psoriasis, Crohn’s disease, eczema, and much more. It is said to work through decreasing the function of lymphocytes. You can find detailed UV spectra of Cyclosporine A and information about its various lambda maxima by visiting the following link.

Cyclosporine B is a calcineurin inhibitor and analogue of cyclosporin A, with the molecular formula C61H109N11O12. It is used primarily as a an immunosuppressant medication with antifungal activities. It is said to work inhibiting P-glycoprotein activity and suppressing the growth of T-lymphoma cell lines. You can find detailed UV spectra of Cyclosporine B and information about its various lambda maxima by visiting the following link.

Cyclosporine C is a cyclic peptide and fungal metabolite, with the molecular formula C62H111N11O13. It is used primarily for its antifungal, antiviral, anti-parasitic, and immunosuppressive properties. It is said to work by inhibiting the vaccinia virus replication in infected cells. Despite that, it displays weaker activity compared to Cyclosporin A. You can find detailed UV spectra of Cyclosporine C and information about its various lambda maxima by visiting the following link

Cyclosporin A, Cyclosporin B, Cyclosporin C can be retained and analyzed using the Primesep 200 stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of acetonitrile and water. Detection is performed using UV.

Condition

ColumnPrimesep 200, 3.2 x 150 mm, 3 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 50/50%
BufferAmmonium Formate pH 3.0 – 10 mM
Flow Rate0.5 ml/min
DetectionESI-SIM: [M+H]+  m/z  1219, 1189, 1203
Temperature of Column60 C

Description

Class of CompoundsDrug
Analyzing CompoundsCyclosporin A, Cyclosporin B, Cyclosporin C

Application Column

Primesep 200

Column Diameter: 3.2 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Cyclosporin A
Cyclosporin B
Cyclosporin C
Application Detection:
LC MS Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Separation of Cyclosporin A, B and C on Primesep 200 Column

September 2, 2026

HPLC Method for Analysis of Cyclosporin A, Cyclosporin B, Cyclosporin C on Primesep 200 by SIELC Technologies

HPLC Method for Analysis of Cyclosporin A, Cyclosporin B, Cyclosporin C in on Primesep 200 Column

Cyclosporine A, also known as cyclosporin and ciclosporin, is a calcineurin inhibitor with the molecular formula C62H111N11O12. It is used primarily as a an immunosuppressant medication to treat rheumatoid arthritis, psoriasis, Crohn’s disease, eczema, and much more. It is said to work through decreasing the function of lymphocytes. You can find detailed UV spectra of Cyclosporine A and information about its various lambda maxima by visiting the following link.

Cyclosporine B is a calcineurin inhibitor and analogue of cyclosporin A, with the molecular formula C61H109N11O12. It is used primarily as a an immunosuppressant medication with antifungal activities. It is said to work inhibiting P-glycoprotein activity and suppressing the growth of T-lymphoma cell lines. You can find detailed UV spectra of Cyclosporine B and information about its various lambda maxima by visiting the following link.

Cyclosporine C is a cyclic peptide and fungal metabolite, with the molecular formula C62H111N11O13. It is used primarily for its antifungal, antiviral, anti-parasitic, and immunosuppressive properties. It is said to work by inhibiting the vaccinia virus replication in infected cells. Despite that, it displays weaker activity compared to Cyclosporin A. You can find detailed UV spectra of Cyclosporine C and information about its various lambda maxima by visiting the following link

Cyclosporin A, Cyclosporin B, Cyclosporin C can be retained and analyzed using the Primesep 200 stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of acetonitrile and water. Detection is performed using UV.

Condition

ColumnPrimesep 200, 3.2 x 150 mm, 3 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 50/50%
BufferNone
Flow Rate0.5 ml/min
DetectionUV 200 nm
Temperature of Column60 C

Description

Class of CompoundsDrug
Analyzing CompoundsCyclosporin A, Cyclosporin B, Cyclosporin C

Application Column

Primesep 200

Column Diameter: 3.2 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

Add to cart
Application Analytes:
Cyclosporin A
Cyclosporin B
Cyclosporin C
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Uv-Vis Spectrum of Cyclosporin C

March 16, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Cyclosporin C check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The compound was dissolved in acetonitrile.

Application Analytes:
Cyclosporin C
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.