Ataciguat

CAS Number254877-67-3
Molecular FormulaC21H19Cl2N3O6S3
Molecular Weight576.5
InChI KeyPQHLRGARXNPFCF-UHFFFAOYSA-N
LogP4.2
Synonyms
  • Ataciguat
  • 254877-67-3
  • HMR-1766
  • HMR1766
  • DTXSID7048746
  • 5-Chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide
  • QP166M390Q
  • DTXCID4028672
  • 5-Chloro-2-((5-chloro-2-thienyl)sulfonylamino)-N-(4-(morpholin-4-ylsulfonyl)phenyl)benzamide
  • 5-chloro-2-(5-chlorothiophene-2-sulfonamido)-N-[4-(morpholine-4-sulfonyl)phenyl]benzamide
  • ataciguatum
  • 5-chloro-2-(5-chlorothiophene-2-sulfonamido)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide
  • RefChem:115399
  • Benzamide, 5-chloro-2-(((5-chloro-2-thienyl)sulfonyl)amino)-N-(4-(4-morpholinylsulfonyl)phenyl)-
  • Ataciguat [INN]
  • HMR 1766
  • 5-Chloro-2-(5-chlorothiophene-2-sulfonamido)-N-(4-(morpholinosulfonyl)phenyl)benzamide
  • 5-chloro-2-[(5-chlorothiophen-2-yl)sulfonylamino]-N-(4-morpholin-4-ylsulfonylphenyl)benzamide
  • 5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide
  • CAS-254877-67-3
  • UNII-QP166M390Q
  • C21H19Cl2N3O6S3
  • Ataciguat?
  • ATACIGUAT [WHO-DD]
  • SCHEMBL491675
  • GTPL5141
  • orb1306280
  • CHEMBL2107729
  • SCHEMBL29370450
  • GLXC-21514
  • Tox21_113203
  • EX-A11166
  • AKOS027326819
  • Tox21_113203_1
  • DB12805
  • FA18005
  • SB16944
  • NCGC00249417-01
  • NCGC00249417-02
  • HY-17500
  • DB-242293
  • CS-0009242
  • NS00069154
  • T21607
  • F799797
  • Q27074574
  • 5-chloro-2-[(5-chloro-2-thienyl)sulfonylamino]-N-(4-morpholinosulfonylphenyl)benzamide

Applications:

HPLC Method for Analysis of Ataciguat on Primesep 100 Column

July 16, 2026

HPLC Method for Analysis of Ataciguat on Primesep 100 Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Ataciguat.

Ataciguat is an drug with the chemical formula C21H19N3O6S3. It is primarily used as a guanylate cyclase activator. Through activating sGC and restoring the NO-cGMP pathways, it helps to reduce calcium deposition, slow valve calcification, and generally treats calcific aortic valve stenosis. t helps reduce calcium deposition You can find detailed UV spectra of Ataciguat and information about its various lambda maxima by visiting the following link.

Ataciguat can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) and ethanol. Detection is performed using UV.

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 50/50 – 80/20%, 10 min
BufferH2SO4 – 0.05%
Flow Rate1.0 ml/min
DetectionUV 241 nm
Limit Of Detection*150 ppb
*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Description

Class of CompoundsDrug
Analyzing CompoundsAtaciguat

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Ataciguat
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Uv-Vis Spectrum of Ataciguat

July 16, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Ataciguat check our HPLC Applications library

UV/Vis.: λmax: 218, 293, 354 nm

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The compound was dissolved in ethanol. This analysis was done with the mobile phase of hexane, IPA, and TFA.

This compound was diluted in a mixture of water and acetonitrile. The method was done with a mixture of water, acetonitrile, and a sulfuric acid buffer.

 

 

 

 

Application Analytes:
Ataciguat
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.