Acetazolamide

Acetazolamide structural formula

CAS Number59-66-5
Molecular FormulaC4H6N4O3S2
Molecular Weight222.241
InChI KeyBZKPWHYZMXOIDC-UHFFFAOYSA-N
LogP-0.260
Synonyms
  • Acetazolamide
  • N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
  • Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-
  • 59-66-5
  • Acetamide, N-[5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl]-
  • 2-Acetamido-1,3,4-thiadiazole-5-sulfonamide
  • 2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
  • 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide
  • 5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
  • 5-Acetamido-1,3,4-thiadiazole-2-sulfonamide
  • 5-Acetamido-1,3,4-thiodiazole-2-sulfonamide
  • 5-Acetylamino-1,3,4-thiadiazol-2-ylsulfonamide
  • Acetamide, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-
  • Acetamox
  • Acetazolamid
  • acetazolamida
  • Atenezol
  • Carbonic anhydrase inhibitor 6063
  • Cidamex
  • Defiltran
  • Dehydratin
  • Diacarb
  • Diakarb
  • Diluran
  • Diuramid
  • Diuramide
  • Diureticum-Holzinger
  • Diuriwas
  • Diutazol
  • Eumicton
  • Fonurit
  • Glaupax
  • N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide
  • N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide
  • Natrionex
  • Nephramid
  • Nephramide
  • NSC 145177
  • Phonurit
  • Acetamidothiadiazolesulfonamide
  • N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide
  • Carbonic Anhydrase Inhibitor No. 6063
  • Duiramid
  • EINECS 200-440-5
  • SK-acetazolamide
  • 1,3,4-Thiadiazole-2-sulfonamide, 5-acetamido-
  • Vetamox
  • Acetazolamidum
  • Glaumox
  • Diamox sequels
  • UNII-O3FX965V0I
  • Diamox
  • 5661-25-6
  • 8017-69-4

Applications:

Separation of Acetazolamide on Newcrom R1 HPLC column

February 19, 2018
Separation of Acetazolamide on Newcrom C18 HPLC column

Acetazolamide is a drug that can treat glaucoma, epilepsy, mountain sickness, periodic paralysis, idiopathic intracranial hypertension, and heart failure. It is a diuretic as well, which makes it effective for mountain sickness. Acetazolamide can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Acetazolamide
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.