α-methylbenzylamine

CAS Number618-36-0
Molecular FormulaC8H11N
Molecular Weight121.1831
InChI KeyRQEUFEKYXDPUSK-UHFFFAOYSA-N
LogP1.2
Synonyms
  • 1-Phenylethanamine
  • 1-Phenylethylamine
  • ALPHA-METHYLBENZYLAMINE
  • alpha-Phenylethylamine
  • 1-Phenethylamine
  • alpha-Aminoethylbenzene
  • 1-Amino-1-phenylethane
  • 98-84-0
  • alpha-Phenethylamine
  • alpha-Methylbenzenemethanamine
  • Sumine 2079
  • Ethanamine, 1-phenyl-
  • Ethylamine, 1-phenyl-
  • (1-Aminoethyl)benzene
  • Benzene, (1-amino-ethyl)-
  • HZ9DM6B2MT
  • Benzylamine, alpha-methyl-
  • Benzenemethanamine, alpha-methyl-
  • Benzenemethaneamine, alpha-methyl-
  • NSC-8391
  • CHEBI:670
  • DTXSID40862301
  • RefChem:555866
  • DTXCID20198913
  • 202-706-6
  • 210-545-8
  • 618-36-0
  • DL-alpha-Methylbenzylamine
  • 1-phenylethan-1-amine
  • DL-1-Phenylethylamine
  • a-methylbenzylamine
  • 1-Fenylethylamin
  • a-phenylethylamine
  • Benzenemethanamine, .alpha.-methyl-
  • (+/-)-1-Phenylethylamine
  • DL-a-methylbenzyla
  • Benzylamine, .alpha.-methyl-
  • 1-Phenyl-ethylamine
  • dl-a-methylbenzylamine
  • .alpha.-Phenethylamine
  • .alpha.-Phenylethylamine
  • a-methylbenzenemethanamine
  • .alpha.-Methylbenzylamine
  • CHEMBL278059
  • Benzenemethaneamine, .alpha.-methyl-
  • (S)-.alpha.-Methylbenzenemethanamine
  • Benzenemethanamine, .alpha.-methyl-, (S)-
  • benzene, (1-aminoethyl)-
  • |A-Methylbenzylamine
  • (1-phenylethyl)amine
  • (S)-alpha-methyl benzylamine
  • DL-alfa-Methylbenzylamine
  • UNII-HZ9DM6B2MT
  • MFCD00008069
  • 1-Fenylethylamin [Czech]
  • (S)-(-)-a-methyl-benzylamine
  • Benzenemethanamine, a-methyl-
  • a-phenethylamine
  • (S)-(-)-.alpha.-Methylbenzylamine
  • Benzenemethanamine, a-methyl-; 1-Phenylethanamine; a-Phenylethylamine
  • HSDB 2742
  • l-phenylethylamine
  • a-aminoethylbenzene
  • NSC 8391
  • 1-phenylethyl amine
  • EINECS 202-706-6
  • EINECS 210-545-8
  • phenylethan-1-amine
  • 1-Phenyl ethylamine
  • DL-1-phenethylamine
  • alpha-methylbezylamine
  • 1-phenyl-ethyl-amine
  • 1-Phenylethanamine
  • #rac-1-phenylethanamine
  • dl-1-phenylethyl amine
  • 1-Phenyl-1-ethanamine
  • alpha-methyl benzylamine
  • alpha-methyl-benzylamine
  • alpha-methylbenzyl amine
  • (rs)-1-phenylethylamine
  • 1(r,s)-phenylethylamine
  • AI3-03116
  • (+)-1-phenylethylamine
  • (-)-1-phenylethylamine
  • alpha-methyl benzyl amine
  • (-)alpha-phenylethylamine
  • racemic 1-phenylethanamine
  • racemic 1-phenylethylamine
  • SCHEMBL830
  • (-)-alpha-phenylethylamine
  • EC 210-545-8
  • (+) alpha-methylbenzylamine
  • (+)-alpha-methylbenzylamine
  • (+)1-phenylethan-1-amine
  • (+/-)-1-phenylethanamine
  • (-)-alpha-methylbenzylamine
  • (RS)-alpha-methylbenzylamine
  • SCHEMBL42208
  • (-)-.alpha.-Phenethylamine
  • (+)-alpha-methyl-benzylamine
  • (-) alpha-methyl-benzylamine
  • (-)-alpha-methyl-benzylamine
  • WLN: 1M1R
  • (+/-)-1-phenyl-ethanamine
  • (+/-)-1-Phenyl-ethylamine
  • alpha-Methylbenzylamine, 99%
  • racemic alpha-methylbenzylamine
  • SCHEMBL159964
  • (S)-1-Amino-1-phenylethane
  • (+)-alpha-methyl benzyl amine
  • (+/-)-1-(phenyl)ethylamine
  • (+/-)-alpha-Methylbenzylamine
  • (-) alpha methyl benzyl amine
  • orb2802437
  • orb3030415
  • SCHEMBL1043886
  • SCHEMBL1382152
  • SCHEMBL3602233
  • SCHEMBL3834885
  • SCHEMBL4701869
  • SCHEMBL7837473
  • (S)-(?)-?-Methylbenzylamine
  • 1-PHENETHYLAMINE [HSDB]
  • .ALPHA.-AMINOETHYLBENZENE
  • L(-)-.alpha.-Methylbenzylamine
  • L-(-)-.alpha.-Phenylethylamine
  • NSC8391
  • (-)-alpha-methylbenzenemethanamine
  • Fr13902
  • ALBB-032928
  • DL-.ALPHA.-METHYLBENZYLAMINE
  • (R)-.alpha.-Methylbenzenemethanamine
  • BDBM50023171
  • EBC-14353
  • MSK162202
  • s6260
  • SBB040514
  • AKOS000119070
  • AKOS016039387
  • racemic alpha-methyl-benzenemethanamine
  • (RS)-.ALPHA.-METHYLBENZYLAMINE
  • .ALPHA.-METHYLBENZENEMETHANAMINE
  • .ALPHA.-METHYLBENZYLAMINE [MI]
  • CS-W013564
  • FP11135
  • PS-4601
  • (+/-)-.ALPHA.-PHENETHYLAMINE
  • (+/-)-.ALPHA.-PHENYLETHYLAMINE
  • (R,S)-.ALPHA. METHYLBENZYLAMINE
  • AS-80972
  • PD124031
  • Benzenemethanamine, .alpha.-methyl-, (R)-
  • BENZYLAMINE, .ALPHA.-METHYL-, DL-
  • DB-015888
  • DB-054000
  • Benzylamine, .alpha.-methyl-, (.+/-.)-
  • M0165
  • NS00001808
  • ST45255353
  • EN300-17925
  • C02455
  • D77753
  • DL-|A-Methylbenzylamine DL-|A-Phenylethylamine
  • ( inverted exclamation mark_)-1-Phenylethylamine
  • Benzenemethanamine, .alpha.-methyl-, (.+/-.)-
  • F208695
  • T201530
  • Q3560549
  • Z57102377
  • F0798-0597
  • D-alpha-Phenylethylamine; R-(+)-alpha-Methylbenzylamine; D(+)-alpha-Methylbenzylamine; (+)-PEA; (R)-(+)-1-Phenylethylamine

Applications:

HPLC Chiral Separation of alpha-methylbenzylamine Enantiomers on Cyralis CM Column

August 27, 2026

HPLC Chiral Method for Analysis of α-methylbenzylamine Enantiomers on Cyralis CM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of α-methylbenzylamine.

α-methylbenzylamine, also known as 1-Phenylethylamine, is an organic compound with the chemical formula C8H11N. It is is a colorless liquid that has been primarily used in chiral resolutions. It also works as a weak monoamine oxidase inhibitor (MAOI).

This application describes a normal-phase chiral HPLC method for the separation of α-methylbenzylamine enantiomers using SIELC’s Cyralis CM chiral column. Cyralis CM is a cellulose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications. For best results, the sample should be prepared fresh for analysis.

α-methylbenzylamine can be retained and analyzed using the Cyralis CM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane, IPA, and 1-butylamine. Detection is performed using UV.

Condition

ColumnCyralis CM, 4.6 x 250 mm, 5 µm, 100 A, normal phase
Mobile PhaseHexane/IPA/1-butylamine
Flow Rate1.0 mL/min
DetectionUV 250 nm
Resolution1.69

Description

Class of CompoundsDrug
Analyzing Compoundsα-methylbenzylamine

Application Column

Cyralis CM

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: normal phase

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Application Analytes:
α-methylbenzylamine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.