Ritonavir

Ritonavir structural formula

CAS Number155213-67-5
Molecular FormulaC37H48N6O5S2
Molecular Weight720.951
InChI KeyNCDNCNXCDXHOMX-XGKFQTDJSA-N
LogP4.63
Synonyms
  • Ritonavir
  • N-[(2S,4S,5S)-4-Hydroxy-1,6-diphenyl-5-({[(1,3-thiazol-5-yl)methoxy]carbonyl}amino)hexan-2-yl]-N2-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
  • Carbamic acid, N-[(1S,2S,4S)-2-hydroxy-4-[[(2S)-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]-1-oxobutyl]amino]-5-phenyl-1-(phenylmethyl)pentyl]-, 5-thiazolylmethyl ester
  • 155213-67-5
  • 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-
  • Abbott 84538
  • 5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate
  • UNII-O3J8G9O825
  • N-[(1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl]-N<sup>2</sup>-(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

Applications:

HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep P column

June 15, 2022

Separation type: Liquid Chromatography Mixed-mode

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir and Ritonavir

Condition
Column Promesep P, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 40-75%
Buffer HClO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV 210nm

Description
Class of Compounds Drug
Analyzing Compounds Nirmatrelvir,  Ritonavir

 

Application Column

Primesep P

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Nirmatrelvir
Ritonavir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Nirmatrelvir and Ritonavir in Paxlovid Tablets on Primesep 100 Column

May 5, 2022

Separation type: Liquid Chromatography Mixed-mode

 

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nirmatrelvir and Ritonavir

Condition
Column Promesep 100, 3.2×100 mm,  100A
Mobile Phase Gradient MeCN – 50-70%
Buffer H2SO4 – 0.5%
Flow Rate 0.5 ml/min
Detection UV 210nm

Description
Class of Compounds Drug
Analyzing Compounds Nirmatrelvir,  Ritonavir

 

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Nirmatrelvir
Ritonavir
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Ritonavir and Ribavirin

August 22, 2008

Separation type: Liquid Chromatography HILIC

Ritonavir and Ribavarin are two drugs which are very different in their properties for HPLC separation. Very hydrophobic and very hydrophilic drugs are separated on Primesep N using Hydrophilic Interaction Chromatography (HILIC). Ritonavir is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS. Ritonavir is very hydrophobic and non-ionizable and retains very long in reverse phase chromatography. Ribavirin is an anti-viral drug which is active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drug, which makes it very hydrophilic.

Condition
Column Primesep N, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN/H2O – 97/3%
Buffer No
Flow Rate 1.0 ml/min
Detection UV 250 nm,  MS- compatible mobile phase

Description
Class of Compounds Drug
Analyzing Compounds Ritonavir,  Ribavirin

Application Column

Primesep N

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

Add to cart
Application Analytes:
Ribavirin
Ritonavir
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.