4-Chlorobenzyl chloride

4-Chlorobenzyl chloride structural formula

CAS Number104-83-6
Molecular FormulaC7H6Cl2
Molecular Weight161.030
InChI KeyJQZAEUFPPSRDOP-UHFFFAOYSA-N
LogP3.18
Synonyms
  • 4-Chlorobenzyl chloride
  • 1-Chloro-4-(chloromethyl)benzene
  • Benzene, 1-chloro-4-(chloromethyl)-
  • 104-83-6
  • 1-Chloro-4-(chloromethyl)benzene
  • Benzene, 1-chloro-4-(chloromethyl)-
  • (4-Chlorophenyl)methyl chloride
  • 1-(Chloromethyl)-4-chlorobenzene
  • BENZYL CHLORIDE, 4-CHLORO-
  • CHLOROBENZYLCHLORIDE
  • NSC 34032
  • p,?-Dichlorotoluene
  • p-Chlorobenzyl chloride
  • P-CHLOROBENZYLCHLORIDE
  • p-Chlorophenylmethyl chloride
  • Toluene, p,?-dichloro-
  • UN 2235
  • ?,4-Dichlorotoluene
  • ?,4-Dichlortoluol
  • ?,p-Dichlorotoluene
  • ?-4-diclorotolueno
  • BRN 0471558
  • alpha,p-Dichlorotoluene
  • EINECS 203-242-7
  • UNII-Q9HS4N7D3M

Applications:

HPLC Method for Analysis of 2-Chlorobenzyl Chloride and 4-Chlorobenzyl Chloride on Newcrom R1 Column

July 9, 2025

HPLC Method for 2-Chlorobenzyl chloride, 4-Chlorobenzyl chloride on Newcrom R1 by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of 2-Chlorobenzyl chloride, 4-Chlorobenzyl chloride

2-Chlorobenzyl Chloride
Pharmaceutical intermediate – used to build drugs with chlorinated aromatic structures.

Agrochemicals – precursor for pesticides and herbicides.

Organic synthesis – for introducing a 2-chlorobenzyl group via nucleophilic substitution.

Dyes and pigments – used in manufacturing colorants.

4-Chlorobenzyl Chloride
Pharmaceuticals – key building block for antihistamines, antidepressants, etc.

Polymer chemistry – used to modify or crosslink polymers.

Agrochemical synthesis – like insecticides and fungicides.

Fine chemicals – intermediate for specialty chemical synthesis.

2-Chlorobenzyl chloride, 4-Chlorobenzyl chloride can be retained and analyzed using the Newcrom R1 column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and phosphoric acid. Detection is performed using UV at 210 nm.

ColumnNewcrom R1, 3.2 x 100 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN -45%
BufferH3PO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 210 nm
LOD6.8 ppb, 9.9 ppb

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Class of CompoundsOrganic Halides (Alkyl Halides / Arylalkyl Halides)
Analyzing Compounds2-Chlorobenzyl chloride, 4-Chlorobenzyl chloride

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
2-Chlorobenzyl chloride
4-Chlorobenzyl chloride

Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of 4-Chlorobenzyl chloride on Newcrom R1 HPLC column

February 16, 2018
Separation of 4-Chlorobenzyl chloride on Newcrom C18 HPLC column

4-Chlorobenzyl chloride can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
4-Chlorobenzyl chloride
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.