Zidesamtinib

CAS Number2739829-00-4
Molecular FormulaC22H22FN7O
Molecular Weight419.5
InChI KeyDTWUUAFTYSMNQX-GFCCVEGCSA-N
LogP2.8
Synonyms
  • Zidesamtinib
  • 2739829-00-4
  • NVL-520
  • NUV-520
  • NU-520
  • NVL520
  • MX5KQV5XHC
  • NU-0002362
  • NU-2362-010
  • NU-0002362-009
  • RefChem:1101134
  • NU-0002362-006
  • zidesamtinib [INN]
  • Zidesamtinib [WHO-DD]
  • Zidesamtinib (USAN/INN)
  • ZIDESAMTINIB [USAN]
  • A1I6Z
  • orb1744545
  • CHEMBL5314497
  • SCHEMBL24007115
  • GTPL12392
  • GLXC-27821
  • EX-A8016
  • NSC853293
  • Example 5 [US383715659]
  • NSC-853293
  • DA-79102
  • HY-152292
  • D12899
  • G87136
  • (14R)-7-ethyl-16-fluoro-2,14-dihydro-2,14-dimethyl-7H-8,12-Metheno-4H-pyrazolo[3,4-h]-1,2,3-triazolo[4,5-k][2,5]benzoxaazacyclotetradecin-11-a mine
  • (14R)-7-Ethyl-16-fluoro-2,14-dihydro-2,14-dimethyl-7H-8,12-metheno-4H-pyrazolo[3,4-h]-1,2,3-triazolo[4,5-k][2,5]benzoxaazacyclotetradecin-11-amine
  • (19R)-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,9,10,11,23-hexazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(25),2(6),4,8,11,13(18),14,16,21,23-decaen-22-amine
  • (R)-3-Ethyl-12-fluoro-10,16-dimethyl-3,10,16,18-tetrahydro-4,8-(metheno)benzo[l]pyrazolo[3,4-g][1,2,3]triazolo[4,5-j][1]oxa[4]azacyclotetradecin-7-amine
  • 7H-8,12-Metheno-4H-pyrazolo[3,4-h]-1,2,3-triazolo[4,5-k][2,5]benzoxaazacyclotetradecin-11-amine, 7-ethyl-16-fluoro-2,14-dihydro-2,14-dimethyl-, (14R)-

Applications:

Uv-Vis Spectrum of Zidesamtinib

August 18, 2026

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If you are looking for optimized HPLC method to analyze Zidesamtinib check our HPLC Applications library

UV/Vis.: λmax: 190, 230,  260, 320 nm

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The compound was dissolved in ethanol. This analysis was done with the mobile phase of hexane, IPA, and TFA.

This compound was diluted in a mixture of water and acetonitrile. The method was done with a mixture of water and acetonitrile.

Application Analytes:
Zidesamtinib
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC MS Method for Analysis of Zidesamtinib on Chromni Column

August 18, 2026

HPLC Method for Analysis of Zidesamtinib on Chromni Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Zidesamtinib.

Zidesamtinib is an anti-cancer medication with the chemical formula C22H22FN7O. It is primarily used to treat non-small cell lung cancer and works as a kinase inhibitor.

Zidesamtinib can be retained and analyzed using the Chromni stationary phase column. The analysis utilizes a gradient method with a simple mobile phase consisting of water and acetonitrile (MeCN) and ethanol. Detection is performed using LC MS.

Condition

ColumnChromni, 3.2 x 100 mm, 3 µm, 100 A, dual ended
Mobile PhaseGradient MeCN/H2O
BufferAmAc pH 5.0 – 10 mM
Flow Rate0.5 ml/min
DetectionLC MS ESI SIM 420 [M+H] +

Description

Class of CompoundsDrugs
Analyzing CompoundsZidesamtinib

Application Column

Chromni

Column Diameter: 3.2 mm
Column Length: 100 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Zidesamtinib
Application Detection:
LC MS Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.