Yohimbine

Yohimbine structural formula

CAS Number146-48-5
Molecular FormulaC21H26N2O3
Molecular Weight354.451
InChI KeyBLGXFZZNTVWLAY-SCYLSFHTSA-N
LogP2.54
Synonyms
  • Yohimbine
  • Methyl (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylate
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16alpha,17alpha)-
  • 146-48-5
  • 4-25-00-01237
  • Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16?,17?)-
  • (+)-Yohimbine
  • Aphrodine
  • Aphrosol
  • Corynine
  • Quebrachin
  • Quebrachine
  • trans-Quinolizidine yohimbine
  • Yohimban-16?-carboxylic acid, 17?-hydroxy-, methyl ester
  • Yohimbic acid methyl ester
  • Yohimbin
  • yohimbina
  • Yohimbol-16?-carboxylic acid, methyl ester
  • BRN 0097276
  • EINECS 205-672-0
  • 17-Hydroxyyohimban-16-carboxylic acid methyl ester
  • UNII-2Y49VWD90Q
  • (16alpha,17alpha)-17-hydroxyyohimban-16-carboxylic acid methyl ester
  • 17alpha-hydroxyyohimban-16alpha-carboxylic acid methyl ester
  • Johimbin

Applications:

Separation of Yohimbine on Newcrom R1 HPLC column

May 16, 2018
Separation of Yohimbine on Newcrom R1 HPLC column

Yohimbine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Yohimbine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.