Propofol

Propofol structural formula

CAS Number2078-54-8
Molecular FormulaC12H18O
Molecular Weight178.275
InChI KeyOLBCVFGFOZPWHH-UHFFFAOYSA-N
LogP3.79
Synonyms
  • Propofol
  • 2,6-Di(propan-2-yl)phenol
  • Phenol, 2,6-bis(1-methylethyl)-
  • 2078-54-8
  • 2,6-Diisopropylphenol
  • 4-06-00-03435
  • Phenol, 2,6-bis(1-methylethyl)-
  • 2,6-Bis(1-methylethyl)phenol
  • 2,6-Bis(isopropyl)phenol
  • Ampofol
  • Diprifusor
  • Diprivan
  • Diprivan 10
  • Diprofol
  • Disoprivan
  • Disoprofol
  • NSC 5105
  • PHENOL, 2,6-DIISOPROPYL-
  • Pronest
  • Propofol-lipuro
  • Propovan
  • Rapinovet
  • Recofol
  • BRN 1866484
  • EINECS 218-206-6
  • Diprivan Injectable emulsion
  • Propofolum
  • UNII-YI7VU623SF
  • Fresofol
  • Propoven
  • 28449-97-0
  • 50356-15-5

Applications:

Uv-Vis Spectrum of Propofol

March 12, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Propofol check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The spectra presented here are measured with an acidic mobile phase that has a pH of 3 or lower.

Application Analytes:
Propofol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Method for Analysis of Propofol on Newcrom R1 Column

February 16, 2018

HPLC Method for Propofol on Newcrom R1 by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Propofol Propofol is an anesthetic agent used in maintenance of general anesthesia and procedural sedation. The drug has a very short recovery period of a couple of minutes, but the side effects include an irregular heart rate, low blood pressure, and possibly the stopping of breathing. Propofol can be retained and analyzed using the Newcrom R1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a phosphoric acid buffer. Detection is performed using UV.
Column Newcrom R1, 3.2 x 150 mm, 3 µm, 100 A, dual ended
Mobile Phase  MeCN – 70%
Buffer Phosphoric Acid
Flow Rate 0.5 ml/min
Detection UV 270 nm
Class of Compounds Anesthetic
Analyzing Compounds Propofol

Application Column

Newcrom R1

Column Diameter: 3.2 mm
Column Length: 150 mm
Particle Size: 3 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Propofol
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.