Procainamide

Procainamide structural formula

CAS Number51-06-9
Molecular FormulaC13H21N3O
Molecular Weight235.331
InChI KeyREQCZEXYDRLIBE-UHFFFAOYSA-N
LogP0.88
Synonyms
  • Procainamide
  • 4-Amino-N-[2-(diethylamino)ethyl]benzamide
  • Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-
  • 51-06-9
  • 4-14-00-01154
  • Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-
  • 4-Amino-N-(diethylaminoethyl)benzamide
  • 4-Amino-N-[2-(diethylamino)ethyl]benzamide
  • Benzamide, p-amino-N-[2-(diethylamino)ethyl]-
  • Novocainamid
  • Novocainamide
  • Novocaine amide
  • Novocamid
  • NSC 27461
  • p-Aminobenzoic diethylaminoethylamide
  • p-Amino-N-(2-diethylaminoethyl)benzamide
  • Procainamid
  • procainamida
  • Procaine amide
  • Procanbid
  • 4-Amino-N-(2-(diethylamino)ethyl)benzamide
  • Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-
  • Biocoryl
  • BRN 2214285
  • EINECS 200-078-8
  • Procamide
  • 2-Diethylaminoethylamid kyseliny p-aminobenzoove
  • Procainamidum
  • UNII-L39WTC366D
  • Rhythmin

Applications:

USP Methods for the Separation of Propranolol and Procainamide Using the Legacy L1 Column

2012-07-23
  Application Notes: Propranolol is a common beta-blocker used for treating anxiety and hypertension, and procainamide is an antiarrhythmic drug. According to the USP methods, propranolol hydrochloride contain no less than 98% and no more than 101.5 percent of propranolol calculated on a dried basis. The USP HPLC method for the separation of phenylephrine and epinephrine was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS. Reference: USP35: NF30

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O/MeOH
Buffer SLS
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Antiarrhythmic, Hydrophobic, Ionizable
Analyzing Compounds Procainamide, Propranolol
 
SIELC Technologies usually develops more than one method for each compound on our website. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound of interest.
Application Analytes:
Procainamide
Propranolol

Application Detection:
UV Detection

USP Methods for the Analysis of Procainamide

2012-07-23
  Application Notes: Procainamide is a common antiarrhythmic agent used to treat cardiac arrhythmias. According to USP methods procainamide hydrochloride contains not less than 98% and no more than 102% procainamide based on the dried basis. The USP HPLC method for the separation of procainamide and 4-aminobenzoic was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of UPS. Reference: USP 35- NF30

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O - 60/40%
Buffer TEAPh pH 7.5
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Antiarrhythmic, Hydrophobic, Ionizable
Analyzing Compounds Procainamide, 4-Aminobenzoic acid
 
SIELC Technologies usually develops more than one method for each compound on our website. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound of interest.
Application Analytes:
4-Aminobenzoic Acid
Procainamide

Application Detection:
UV Detection

USP Methods for the Separation of Propranolol and Procainamide using a Legacy L1 Column

2012-06-21
  Application Notes: Propranolol is a common beta-blocker used for treating anxiety and hypertension, and procainamide is an antiarrhythmic drug. According to the USP methods, propranolol hydrochloride contain no less than 98% and no more than 101.5 percent of propranolol calculated on a dried basis. The USP HPLC method for the separation of phenylephrine and epinephrine was developed on Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A. Resolution between critical pairs corresponds to rules and specifications of USP. Application Columns: Legacy L1 C18 HPLC column Application compounds: Propranolol and procainamide Mobile phase: Water/MeOH/MeCN (70/70/90) with 7mM sodium lauryl sulfate and 11 mM phosphoric acid Detection technique: UV Reference: USP35: NF30

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase Water/MeOH/MeCN (70/70/90) with 7mM Sodium Lauryl   sulfate and 11   mM Phosphoric acid
Buffer Sodium Lauryl   Sulfate, Phosphoric acid
Flow Rate 1.0 ml/min
Detection UV, 270 nm
 

Description

Class of Compounds Drug, Beta blocker, Antiarrhythmic, Hydrophobic, Ionizable, Neutral
Analyzing Compounds Propranolol, Procainamide
 
SIELC Technologies usually develops more than one method for each compound on our website. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound of interest.
Application Analytes:
Procainamide
Propranolol

USP Methods Analysis of Procainamide Legacy L1 Column

2012-06-21
  Application Columns: Legacy L1 C18 HPLC column Application compounds: Procainamide and 4-aminobenzoic acid Mobile phase: WAter/MeOH/MeCN (70/70/90) with 7 mM sodium lauryl sulfate and 11mM phosphoric acid Detection technique: UV Reference: USP35: NF30

Condition

Column Legacy L1, 4.6x150 mm, 5 µm, 100A
Mobile Phase Water/MeOH/TEA (140/60/1)   adjusted to pH 7.5 with H3PO4
Buffer TEAPh
Flow Rate 1.5 ml/min
Detection UV, 230 nm
 

Description

Class of Compounds Drug, Nonsteroidal anti-inflammatory drug, Hydrophobic, Ionizable
Analyzing Compounds Ibuprofen, benzophenone
 
SIELC Technologies usually develops more than one method for each compound on our website. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound of interest.
Application Analytes:
4-Aminobenzoic Acid
Procainamide
Procainamide Hydrochloride

Application Detection:
UV Detection