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UV-Vis Spectrum of Procaine, Procaine hydrochloride. Absorption Maxima: 194 nm, 223 nm, 294 nm.

If you are looking for optimized HPLC method to analyze Procaine, Procaine hydrochloride check our HPLC Applications library

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.

High Performance Liquid Chromatography (HPLC) Method for Analysis of Procaine on Primesep 200 by SIELC Technologies

Procaine is a local anesthetic drug with the chemical formula C₁₃H₂₀N₂O₂. It belongs to the amino ester group of local anesthetics. It is employed for local anesthesia, providing pain relief in various medical and dental settings. Procaine works by blocking nerve impulses and causing temporary loss of sensation in a specific area of the body. It is usually administered through injection to induce local anesthesia. You can find detailed UV spectra of Procainamide, Procaine and information about its various lambda maxima by visiting the following link.

Procaine can be retained and analyzed using a Primesep 200 mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and ammonium formate as a buffer. This method allows for detection using UV at 294 nm

High Performance Liquid Chromatography (HPLC) Method for Analysis of Procainamide, Procaine on BIST B+ by SIELC Technologies

Procainamide is an antiarrhythmic medication with the chemical formula C₁₃H₂₁N₃O. It belongs to the Class Ia antiarrhythmic drugs. It is used to treat certain types of abnormal heart rhythms (arrhythmias) by stabilizing the cell membrane and reducing excitability in the heart muscle. Procainamide works by inhibiting sodium channels in cardiac cells, prolonging the action potential duration and refractory period, which helps in controlling irregular heartbeats. It is typically administered intravenously or orally under medical supervision.

Procaine is a local anesthetic drug with the chemical formula C₁₃H₂₀N₂O₂. It belongs to the amino ester group of local anesthetics. It is employed for local anesthesia, providing pain relief in various medical and dental settings. Procaine works by blocking nerve impulses and causing temporary loss of sensation in a specific area of the body. It is usually administered through injection to induce local anesthesia. You can find detailed UV spectra of Procainamide, Procaine and information about its various lambda maxima by visiting the following link.

Procainamide, Procaine can be retained, separated and analyzed on a BIST B+ mixed-mode stationary phase column using an analytical method with a simple mobile phase of water, Acetonitrile (MeCN) , and a sulfuric acid as a buffer. This analysis method can be detected using UV at 280 nm.

Condition

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed

Description

HPLC Method for Analysis of Procainamide, Procaine on Newcrom A by SIELC Technologies

Procainamide is an antiarrhythmic medication with the chemical formula C₁₃H₂₁N₃O. It belongs to the Class Ia antiarrhythmic drugs. It is used to treat certain types of abnormal heart rhythms (arrhythmias) by stabilizing the cell membrane and reducing excitability in the heart muscle. Procainamide works by inhibiting sodium channels in cardiac cells, prolonging the action potential duration and refractory period, which helps in controlling irregular heartbeats. It is typically administered intravenously or orally under medical supervision.

Procaine is a local anesthetic drug with the chemical formula C₁₃H₂₀N₂O₂. It belongs to the amino ester group of local anesthetics. It is employed for local anesthesia, providing pain relief in various medical and dental settings. Procaine works by blocking nerve impulses and causing temporary loss of sensation in a specific area of the body. It is usually administered through injection to induce local anesthesia. You can find detailed UV spectra of Procainamide, Procaine and information about its various lambda maxima by visiting the following link.

Procainamide is primarily used for cardiac conditions, while procaine is utilized as a local anesthetic for pain management during medical and dental procedures. While both compounds have a shared ancestry in PABA and contain amine groups, the specific functional groups (amide vs. ester) and their positions in the molecules contribute to their distinct pharmacological properties. It’s a good observation that small structural changes can lead to significant differences in the pharmacological actions of compounds.

Procainamide, Procaine can be retained, separated and analyzed using a Newcrom A mixed-mode stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and phosphoricacid as a buffer. Detection is achieved using UV 280 nm