Procaine

High Performance Liquid Chromatography (HPLC) Method for Analysis of Procaine on Primesep 200 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode SIELC Technologies

 High Performance Liquid Chromatography (HPLC) Method for Analysis of Procaine

Procaine is a local anesthetic drug that belongs to the class of amino esters. It is often used to numb specific areas of the body during medical procedures or minor surgeries. Procaine works by blocking nerve signals in the body, leading to a temporary loss of sensation in the treated area.

Some common uses of procaine include dental procedures, minor skin surgeries, and as an ingredient in certain formulations for pain relief. It is often combined with other medications, such as benzyl alcohol, to enhance its stability and effectiveness.

Procaine can be retained and analyzed using a Primesep 200 mixed-mode stationary phase column. The analysis employs an isocratic method with a simple mobile phase comprising water, acetonitrile (MeCN), and ammonium formate as a buffer. This method allows for detection using UV at 294 nm

High Performance Liquid Chromatography (HPLC) Method for Analysis of Procainamide, Procaine on BIST B+ by SIELC Technologies

Separation type: Bridge Ion Separation Technology, or BIST™ by SIELC Technologies

Procainamide and procaine are two different pharmaceutical compounds with distinct uses and properties.

Procainamide:

Class: Procainamide is an antiarrhythmic medication, belonging to the Class Ia antiarrhythmic drugs. It is used to treat certain types of abnormal heart rhythms (arrhythmias) by stabilizing the cell membrane and reducing excitability in the heart muscle.
Mechanism of Action: Procainamide works by inhibiting sodium channels in cardiac cells, prolonging the action potential duration and refractory period, which helps in controlling irregular heartbeats.
Administration: It is typically administered intravenously or orally under medical supervision.
Medical Use: Procainamide is prescribed for conditions such as atrial and ventricular arrhythmias.
Procaine:

Class: Procaine is a local anesthetic drug, belonging to the amino ester group of local anesthetics.
Mechanism of Action: Procaine works by blocking nerve impulses and causing temporary loss of sensation in a specific area of the body.
Administration: It is usually administered through injection to induce local anesthesia. Procaine is commonly used for minor surgical procedures and dental work.
Medical Use: Procaine is employed for local anesthesia, providing pain relief in various medical and dental settings.
Procainamide is primarily used for cardiac conditions, while procaine is utilized as a local anesthetic for pain management during medical and dental procedures. While both compounds have a shared ancestry in PABA and contain amine groups, the specific functional groups (amide vs. ester) and their positions in the molecules contribute to their distinct pharmacological properties. It’s a good observation that small structural changes can lead to significant differences in the pharmacological actions of compounds.

Procainamide and procaine can be retained, separated and analyzed on a BIST B+ mixed-mode stationary phase column using an analytical method with a simple mobile phase of water, Acetonitrile (MeCN) , and a sulfuric acid as a buffer. This analysis method can be detected using UV at 280 nm.

High Performance Liquid Chromatography (HPLC) Method for Analyses of Procainamide, Procaine

Condition

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed

Description

HPLC Method for Analysis of Procainamide, Procaine on Newcrom A by SIELC Technologies

 High Performance Liquid Chromatography (HPLC) Method for Analysis of Procainamide, Procaine

Procainamide and procaine are two different pharmaceutical compounds with distinct uses and properties.

Procainamide:

• Class: Procainamide is an antiarrhythmic medication, belonging to the Class Ia antiarrhythmic drugs. It is used to treat certain types of abnormal heart rhythms (arrhythmias) by stabilizing the cell membrane and reducing excitability in the heart muscle.
• Mechanism of Action: Procainamide works by inhibiting sodium channels in cardiac cells, prolonging the action potential duration and refractory period, which helps in controlling irregular heartbeats.
• Administration: It is typically administered intravenously or orally under medical supervision.
• Medical Use: Procainamide is prescribed for conditions such as atrial and ventricular arrhythmias.

Procaine:

• Class: Procaine is a local anesthetic drug, belonging to the amino ester group of local anesthetics.
• Mechanism of Action: Procaine works by blocking nerve impulses and causing temporary loss of sensation in a specific area of the body.
• Administration: It is usually administered through injection to induce local anesthesia. Procaine is commonly used for minor surgical procedures and dental work.
• Medical Use: Procaine is employed for local anesthesia, providing pain relief in various medical and dental settings.

Procainamide is primarily used for cardiac conditions, while procaine is utilized as a local anesthetic for pain management during medical and dental procedures. While both compounds have a shared ancestry in PABA and contain amine groups, the specific functional groups (amide vs. ester) and their positions in the molecules contribute to their distinct pharmacological properties. It’s a good observation that small structural changes can lead to significant differences in the pharmacological actions of compounds.

 Procainamide and Procaine can be retained, separated and analyzed using a Newcrom A mixed-mode stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and phosphoricacid as a buffer. Detection is achieved using UV 280 nm