Meloxicam

Meloxicam structural formula

CAS Number71125-38-7
Molecular FormulaC14H13N3O4S2
Molecular Weight351.400
InChI KeyZRVUJXDFFKFLMG-UHFFFAOYSA-N
LogP3.43
Synonyms
  • Meloxicam
  • 4-Hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-1,1-dioxo-1,2-dihydro-1lambda6,2-benzothiazine-3-carboxamide
  • 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-, 1,1-dioxide
  • 71125-38-7
  • 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-, 1,1-dioxide
  • Coxflam
  • Melonex
  • Metacam
  • Mobicox
  • Movalis
  • Revmoksikam
  • Meloxicamum
  • Meloxivet
  • Movatec
  • Maxicam
  • Coxicam
  • UNII-VG2QF83CGL

Applications:

HPLC Determination of Meloxicam on Newcrom R1 Column

March 17, 2021

Separation type: Liquid Chromatography Mixed-mode




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High Performance Liquid Chromatography (HPLC) Method for Analysis of Meloxicam.

Meloxicam is a non-steroidal anti-inflammatory drug with anti-inflammatory, antipyretic and analgesic activities. Meloxicam can be retained in HPLC on Newcrom R1 column with the simple isocratic mobile phase consisting of acetonitrile (MeCN) and water with sulfuric acid (H2SO4) buffer. The analysis method can be UV detected at 362nm.




 

Condition
Column Newcrom R1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeCN – 50%
Buffer H2SO4 – 0.1%
Flow Rate 1.0 ml/min
Detection 362 nm

Description
Class of Compounds Drug, Hydrophobic
Analyzing Compounds Meloxicam

 

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Meloxicam
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Separation of Meloxicam on Newcrom R1 HPLC column

February 16, 2018
Separation of Meloxicam on Newcrom C18 HPLC column

Meloxicam can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

Select options
Application Analytes:
Meloxicam
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.