Megestrol acetate

Megestrol acetate structural formula

CAS Number595-33-5
Molecular FormulaC24H32O4
Molecular Weight384.516
InChI KeyRQZAXGRLVPAYTJ-GQFGMJRRSA-N
LogP3.72
Synonyms
  • Megestrol acetate
  • 6-Methyl-3,20-dioxopregna-4,6-dien-17-yl acetate
  • Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
  • 595-33-5
  • Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
  • 17-acetate de 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione
  • 17-acetato de 17-hidroxi-6-metilpregna-4,6-dieno-3,20-diona
  • 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
  • 17-Hydroxy-6-methylpregna-4,6-dien-3,20-dion-17-acetat
  • 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
  • 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
  • 17?-Acetoxy-6-dehydro-6-methylprogesterone
  • 17?-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
  • 17?-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
  • 6-Dehydro-6-methyl-17?-acetoxyprogesterone
  • 6-Methyl-17?-acetoxy-4,6-pregnadiene-3,20-dione
  • 6-Methyl-17?-hydroxy-?6-progesterone acetate
  • 6-Methyl-6-dehydro-17?-acetoxyprogesterone
  • 6-Methyl-?4,6-pregnadien-17?-ol-3,20-dione acetate
  • Magestin
  • Maygace
  • Megeron
  • Megestat
  • Megestil
  • Megestin
  • Megestryl acetate
  • Niagestin
  • NSC 71423
  • Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, acetate
  • 17alpha-Acetoxy-6-dehydro-6-methylprogesterone
  • 17-alpha-Acetoxy-6-dehydro-6-methylprogesterone
  • 17alpha-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
  • 6-Dehydro-6-methyl-17-alpha-acetoxyprogesterone
  • 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
  • EINECS 209-864-5
  • 6-Methyl-17-alpha-acetoxypregna-4,6-diene-3,20-dione
  • 6-Methyl-6-dehydro-17-alpha-acetoxyprogesterone
  • 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone
  • 6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate
  • 6-Methyl-17-alpha-hydroxy-delta(sup 6)-progesterone acetate
  • 6-Methyl-delta(sup 6)-dehydro-17-alpha-acetoxyprogesterone
  • 6-Methyl-delta(sup 4,6)-pregnadien-17-alpha-ol-3,20-dione acetate
  • NSC-71423
  • 17alpha-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
  • 6-Methyl-delta4,6-pregnadien-17alpha-ol-3,20-dione acetate
  • Pallace
  • Megace ES
  • UNII-TJ2M0FR8ES

Applications:

Separation of Megestrol acetate on Newcrom R1 HPLC column

May 16, 2018
Separation of Megestrol acetate on Newcrom R1 HPLC column

Megestrol acetate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Megestrol acetate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.