HPLC Method for Analysis of Suzetrigine on Primesep B Column

HPLC Method for Suzetrigine on Primesep B by SIELC Technologies

HPLC Method for Analysis of Suzetrigine on Primesep B Column by SIELC Technologies


High Performance Liquid Chromatography (HPLC) Method for Analysis of Suzetrigine

Suzetrigine is a selective NaV1.8 sodium channel inhibitor designed for pain management. By targeting peripheral sensory neurons, it reduces pain transmission while minimizing central nervous system effects. Its unique selectivity and novel mechanism make it a valuable compound for pharmaceutical research and development.

Suzetrigine can be retained and analyzed using the Primesep B stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water, acetonitrile (MeCN), and sulfuric acid. Detection is performed using UV at 250 nm.

ColumnPrimesep B, 4.6 x 150 mm, 5 µm, 100 A
Mobile PhaseMeCN/H2O – 50/50%
BufferH2SO4 – 0.1%
Flow Rate1.0 ml/min
DetectionUV 250 nm
LOD7.1 ppb

*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Class of CompoundsSodium Channel Blocker
Analyzing CompoundsSuzetrigine

Application Column

Primesep B

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Suzetrigine
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.