HPLC Method for Naproxen, Naproxen Sodium on Primesep 100 by SIELC Technologies
High Performance Liquid Chromatography (HPLC) Method for Analysis of Naproxen, Naproxen Sodium.
Naproxen is a common NSAID used for pain relief and fever reducer. It has the chemical formula C14H14O3. It works through inhibiting the body’s production of prostaglandins, therefore preventing pain and inflammation. It is available over-the-counter at lower dosages, and through prescription at higher dosages. As a NSAID, it carries a risk of heart attack, stroke, and gastrointestinal bleeding.
You can find detailed UV spectra of Naproxen, Naproxen Sodium and information about its various lambda maxima by visiting the following link.
Naproxen, Naproxen Sodium can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.
| Column | Primesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended |
| Mobile Phase | MeCN/H2O – 40/60% |
| Buffer | H2SO4 – 0.1% |
| Flow Rate | 1.0 ml/min |
| Detection | UV, 270 nm |
| Class of Compounds |
Drug, Hydrophobic, Ionizable |
| Analyzing Compounds | Naproxen, Naproxen Sodium |
Application Column
Primesep 100
Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended
Naproxen Sodium
