HPLC Chiral Separation of Bisphenol A diglycidyl ether Enantiomers on Cyralis AM Column

HPLC Chiral Method for Analysis of Bisphenol A diglycidyl ether Enantiomers on Cyralis AM Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Bisphenol A diglycidyl ether.

Bisphenol A diglycidyl ether (BADGE or DGRBA) is a liquid epoxy resin with the chemical formula C21H24O4. It is a key component of commercially available resins as well as other formulations. It reacts with a variety of compounds to create various resins. For example, if BADGE reacts with acrylic acid, it will produce vinyl ester resin.

This application describes a normal-phase chiral HPLC method for the separation of Bisphenol A diglycidyl ether enantiomers using SIELC’s Cyralis AM chiral column. Cyralis AM is an amylose-based chiral stationary phase (CSP) designed for enantiomeric separations, optical purity testing, chiral impurity analysis, and stereoisomer characterization in pharmaceutical, chemical, agrochemical, and fine chemical applications.

Bisphenol A diglycidyl ether can be retained and analyzed using the Cyralis AM stationary phase column. The analysis utilizes an isocratic method with a mobile phase consisting of Hexane and Ethanol. Detection is performed using UV.

Condition

ColumnCyralis AM, 4.6 x 250 mm, 5 µm, 100 A, normal phase
Mobile PhaseHexane/Ethanol
Flow Rate1.0 mL/min
DetectionUV 210 nm
Resolution1-2: 1.87, 2-3: 2.13

Description

Class of CompoundsResin
Analyzing CompoundsBisphenol A diglycidyl ether

Application Column

Cyralis AM

Column Diameter: 4.6 mm
Column Length: 250 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: normal phase

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Application Analytes:
Bisphenol A diglycidyl ether
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.