Nitrofurantoin

Nitrofurantoin structural formula

CAS Number67-20-9
Molecular FormulaC8H6N4O5
Molecular Weight238.159
InChI KeyNXFQHRVNIOXGAQ-UHFFFAOYSA-N
LogP-0.470
Synonyms
  • Nitrofurantoin
  • 1-{[(5-Nitrofuran-2-yl)methylidene]amino}imidazolidine-2,4-dione
  • 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]-
  • 67-20-9
  • 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]-
  • 1-(5-Nitro-2-furfurylidenamino)hydantoin
  • 1-(5-Nitro-2-furfurylideneamino)hydantoin
  • 1-[(5-Nitrofurfurylidene)amino]hydantoin
  • 5-Nitrofurantoin
  • Berkfurin
  • Chemiofuran
  • Cyantin
  • Furachel
  • Furadantin
  • Furadantine MC
  • Furadantoin
  • Furadoin
  • Furadoine
  • Furadonin
  • Furadonine
  • Furadontin
  • Furalan
  • Furantoin
  • Furantoina
  • Furatoin
  • Furobactina
  • Furophen T-Caps
  • Fur-ren
  • Hydantoin, 1-[(5-nitrofurfurylidene)amino]-
  • Macrobid
  • Macrodantin
  • N-(5-Nitro-2-furfurylidene)-1-aminohydantoin
  • N-(5-Nitro-2-furfurylidine)-1-aminohydantoin
  • N-(5-Nitrofurfurylidene)-1-aminohydantoin
  • Nifurantin
  • nitrofurantoina
  • Nitrofurantoine
  • Novofuran
  • NSC 2107
  • NSC 44150
  • Orafuran
  • Parfuran
  • Trantoin
  • Urantoin
  • Urizept
  • Urofurin
  • Urolong
  • Uro-Tablinen
  • Welfurin
  • Zoofurin
  • Benkfuran
  • Berkfuran
  • Dantafur
  • EINECS 200-646-5
  • Fua Med
  • Furadantine
  • Furadoninum
  • Furagin
  • Furaloid
  • NCI-C55196
  • Nierofu
  • Nitrofuradantin
  • 1-((5-Nitrofurfurylidene)amino)hydantoin
  • Nitrofur-C
  • Furedan
  • Alfuran
  • Ceduran
  • Cistofuran
  • Furabid
  • Furadantin Retard
  • Furadantina MC
  • Furadantine-MC
  • Furophen T
  • Gerofuran
  • Macrodantina
  • Macrofuran
  • Macrofurin
  • Nifuretten
  • Phenurin
  • PiyEloseptyl
  • Ro-Antoin
  • Siraliden
  • Uerineks
  • Urofuran
  • Urolisa
  • Uro-Selz
  • Nitrofurantoin, macrocrystalline
  • N-(5-Nitro-2-furfurylideno)-1-aminohydantoina
  • Nitrofurantoinum
  • UNII-927AH8112L

Applications:

Application USP Methods for Nitrofurantoin for the Legacy L1

February 20, 2019

HPLC Method for Nitrofurantoin on Legacy L1 by SIELC Technologies

Application USP Methods for Nitrofurantoin for the Legacy L1

High Performance Liquid Chromatography (HPLC) Method for Analysis of Nitrofurantoin.

Nitrofurantoin is an oral antibiotic with the chemical formula C8H6N4O5. It is used to treat urinary tract infections.

Nitrofurantoin can be retained and analyzed using the Legacy L1 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN) with a sulfuric acid buffer. Detection is performed using UV.

Condition
Column Legacy L1, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile Phase MeCN/H2O – 43/55%
Buffer NaHPO4 pH3.5 – 2%
Flow Rate 1.0 ml/min
Detection UV, 233 nm

 

Description
Class of Compounds
 Drug, Acid, Ionizable,  Hydrophobic
Analyzing Compounds Nitrofurantoin

 

Application Column

SIELC Legacy L1 HPLC column

Legacy L1

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Nitrofurantoin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Antibiotics in Fish Production

August 22, 2008

Five antibiotics are separated on Primesep C mixed-mode cation-exchange column using UV, ESLD and LC/MS compatible conditions. Similar compounds can be separated based on reverse phase and cation-exchange mechanisms. Current method can be used in quantitative determination of antibiotics in various food products.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

HPLC Separation of Common Antibiotics in Fish Farming

December 6, 2007

Fish antibiotics are used in fish farming to treat bacterial diseases of fish. It is common practice in the fish industry, particularly in developing countries, to use large amounts of antibiotics to prevent infection. The antibiotics used are often non-biodegradable and remain in the environment for long periods of time, contaminating soil and ground waters. In farming antibiotics are mixed with food and residual amount of drugs ends up in fish products and poultry, this lead to consumption of antibiotics and metabolites by humans. Five common antibiotics are separated on Primesep C column using LC/MS compatible conditions. Method can be used for quantitative determination of nitrofurantoin, nitrofurazone, furazolidone, furaltadone, chloramphenicol and nitrofurazone in fish products and environment.

Application Column

Primesep C

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
5-Nitro-2-Furaldehyde Semicarbazone (Nitrofurazone)
Chloramphenicol
Furaltadone
Furazolidone
Nitrofurantoin
Nitrofurazone
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.