Guaifenesin

Guaifenesin structural formula

CAS Number93-14-1
Molecular FormulaC10H14O4
Molecular Weight198.219
InChI KeyHSRJKNPTNIJEKV-UHFFFAOYSA-N
LogP1.39
Synonyms
  • Guaifenesin
  • 3-(2-Methoxyphenoxy)propane-1,2-diol
  • 1,2-Propanediol, 3-(2-methoxyphenoxy)-
  • 93-14-1
  • 4-06-00-05576
  • 1,2-Propanediol, 3-(2-methoxyphenoxy)-
  • 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane
  • 1,2-Propanediol, 3-(o-methoxyphenoxy)-
  • 3-(2-Methoxyphenoxy)-1,2-propanediol
  • 3-(o-Methoxyphenoxy)-1,2-propanediol
  • Actifed C
  • Aeronesin
  • Amonidren
  • Calmipan
  • Colrex Expectorant
  • Equicol
  • Glycerin guaiacolate
  • Glycerol guaiacolate
  • Glycerol α-(2-methoxyphenyl) ether
  • Glycerol α-(o-methoxyphenyl)ether
  • Glycerol α-guaiacyl ether
  • Glyceryl guaiacol ether
  • Glyceryl guaiacolate
  • Glyceryl guaiacolate ether
  • Glyceryl guaiacyl ether
  • Glycerylguaiacol
  • Glycodex
  • Glycotuss
  • Guaiacol glycerin ether
  • Guaiacol glycerol ether
  • Guaiacol glycerolether
  • GUAIACOL GLYCERYL ETHER
  • Guaiacuran
  • Guaiacurane
  • Guaiacyl glyceryl ether
  • Guaiamar
  • Guaianesin
  • guaifenesina
  • Guaifenesine
  • Guaiphenesin
  • Guaiphenesine
  • Guajacuran
  • Guayanesin
  • Hustosil
  • Methoxypropanediol
  • Methphenoxydiol
  • Miocurin
  • Mucinex
  • Muskurelax
  • Myocain
  • Myocaine
  • Myoscain
  • Neuroton
  • Neurotone
  • NSC 62112
  • o-Methoxyphenyl glyceryl ether
  • Organidin NR
  • PROPANE-1,2-DIOL, 3-(2-METHOXYPHENOXY)-
  • racemic-Guaifenesin
  • Relaxil G
  • Reorganin
  • Respenyl
  • Ritussin
  • Robitussin
  • Sirotol
  • Tenntus
  • Tenntuss
  • α-Glyceryl guaiacol ether
  • α-Glyceryl guaiacolate ether
  • Aether glycerinoguaiacolicus
  • Breonesin
  • BRN 2049375
  • Bronchol
  • Cortussin
  • Dorassin
  • EINECS 202-222-5
  • Flartussin
  • Gaiamar
  • Glycerin monoguaiacol ether
  • Glycerinmonoguaiacol ether
  • Glycero-guaiacol ether
  • Glycerol alpha-guaiacyl ether
  • Glycerol alpha-guiacyl ether
  • Glycerol alpha-(o-methoxyphenyl) ether
  • Glycerol alpha-(2-methoxyphenyl) ether
  • Glycerol alpha-(o-methoxyphenyl)ether
  • Glycerol alpha-monoguaiacol ether
  • Glycerol mono(2-methoxyphenyl) ether
  • Glycerol mono(2-methoxyphenyl)ether
  • Glycerol-alpha-monoguaiacol ether
  • Glyceryl guaiacol
  • alpha-Glyceryl guaiacol ether
  • alpha-Glyceryl guaiacolate ether
  • Glyceryl guaicolate
  • Glyceryl guiacolate
  • Gnaifenesin
  • Guaiacolglicerinetere
  • Guaiacolic acid, ester with glycerol
  • Guaia-rom
  • Guaicol glycerine ether
  • Guaicol glyceryl ether
  • Guaiphesin
  • Guajacol-alpha-glycerinether
  • Guajamar
  • Guiaphenesin
  • Hustodil
  • Metfenossidiolo
  • 3-o-Methoxyphenoxypropane 1:2-diol
  • Metossipropandiolo
  • Mintosyl
  • Miocaina
  • Miorelax
  • Mucostop
  • Myorelax
  • Myoscaine
  • 1,2,3-Propanetriol, ether with 2-methoxyphenol
  • Propanosedyl
  • Reduton
  • Relaxyl-G
  • (component of) Deconsal II
  • Glycerol-alpha-guajakolether
  • Guaifenesinum
  • Guajacol-glycerinaether
  • UNII-495W7451VQ
  • 12041-73-5
  • 128707-44-8
  • 1336-67-0

Applications:

HPLC Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 Column

2023-01-12

High Performance Liquid Chromatography (HPLC) Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 by SIELC Technologies

Separation type: Liquid Chromatography Mixed-mode

HPLC Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 Column
HPLC Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol on Primesep 200 Column by SIELC Technologies

Terbutaline Sulfate is a β2 analyst typically used as a prescription-strength cough suppressant. Guaifenesin, also known as Glyceryl Guaiacolate, is a popular expectorant used to treat chest congestion. Ambroxol is a well-known expectorant that targets and breaks down phlegm. Together, these three medicinal compounds are typically found as the active ingredients in many cough syrups. They can be retained, analyzed, and separated on a Primesep 200 mixed-mode column using an isocratic analytical method with a simple mobile phase of water, Acetonitrile (MeCN), and a Phosphoric acid (H3PO4) ionic modifier. This analysis method can be detected in the low UV regime at 210 nm.

High Performance Liquid Chromatography (HPLC) Method for Separation of Terbutaline Sulfate, Guaifenesin and Ambroxol

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Condition

ColumnPrimesep 200, 4.6×150 mm, 5 µm, 100A
Mobile PhaseMeCN/H2O – 30/70%
BufferH3PO4 – 0.05%
Flow Rate1.0 ml/min
DetectionUV 210 nm
Peak Retention Time2.09, 3.28, 5.81 min

Description

Class of CompoundsDrugs
Analyzing CompoundsTerbutaline Sulfate, Guaifenesin and Ambroxol
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Primesep 200

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A

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Application Analytes:
Ambroxol Hydrochloride
Guaifenesin
Terbutaline

USP Methods for the Analysis of Guaifenesin Using a Legacy L1 Column

2012-06-21

 

Application Notes: Guaifenesin is common, over the counter expectorant. Guaifenesin contain no less than 98 percent and not more than 102 percent of the labeled amount of guaifenesin calculated on a dried basis, according to the USP methods. the The USP HPLC method for the analysis of guaifenesin was developed on our Legacy L1 column according to the US Pharmacopeia methodology. L1 classification is assigned to reversed-phase HPLC column containing C18 ligand. Support for the material is spherical silica gel with particles size 3-10 um and pore size of 100-120A.

Application Columns: Legacy L1 C18 HPLC column

Application compounds: Guaifenesin, benzoic acid

Mobile phase: MeOH/H2O/AcOH 40:60:1.5

Detection technique: UV

Reference: USP 35- NF30

 

Condition

Column Legacy L1, 4.6×150 mm, 5 µm, 100A
Mobile Phase MeOH/H2O/AcOH 40/60/1.5
Buffer NaH2PO4
Flow Rate 1.0 ml/min
Detection UV, 270 nm

 

Description

Class of Compounds
Drug, Antibiotics, Hydrophobic, Ionizable, Acid
Analyzing Compounds Guaifenesin, Benzoic acid

 

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
SIELC Legacy L1 HPLC column

Legacy L1

SIELC’s family of Legacy columns is based on United States Pharmacopeia’s (USP) published chromatographic methods and procedures. A plethora of brands have columns used in USP reference standards and methods, and USP has created different designations to group together columns with similar types of packing and properties in the solid phase. SIELC's Legacy columns adhere to these strict requirements and properties so that you can easily replace older columns that are no longer available without having to significantly modify your method or SOPs.

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Application Analytes:
Benzoic Acid
Guaifenesin

Application Detection:
UV Detection

HPLC Separation of Polar Drugs with MS-compatible Method

2010-10-12


Acetaminophen is an over-the-counter pain and fever reducer, and a major component of cold and flue remedies. Phenylephrine is a decongestant. Guaifenesin is a mucolytic agent used to relieve respiratory difficulties. These three compounds of cough medication were separated by mixed-mode chromatography on a Primesep C HPLC column. Retention and order of elution for phenylephrine can be changed by buffer concentration and buffer pH. Method can be used for analysis of cough and cold composition during the production and in QC/QA environment. Method is compatible with LC/MS and can be used to analyze these components in biological fluids. This generic HPLC method is robust and reproducible.

Condition

Column Primesep C, 3×150 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmAc
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

 

Description

Class of Compounds
Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Pseudoephedrine, Guaifenesin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Primesep C

The Primesep family of mixed-mode columns offer a wide variety of stationary phases with an unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method development service which is available for all customers. Ask about our special custom LC-phases tailored for specific separations.

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Application Analytes:
Acetaminophen (Paracetamol)
Guaifenesin
Phenylephrine

Application Detection:
UV Detection

Effect of pH on Retention of Basic Compounds on Primesep C Columns

2010-01-13


Method for separation of components of cough medication shows how retention for acetaminophen, phenylephrine and guaifenesin is controlled. Order of elution for compounds can be changed based on composition of the mobile phase. The method is compatible with UV, ELSD and LC/MS and can be used for quantitation of drugs in formulation. Primesep C mixed-mode HPLC column is ideal candidate for analysis of cough compositions. Basic compounds are well retained in mixed-mode chromatography without use of ion-pairing reagents. Several companies validated this approach. The method is reproducible and robust and can be used in both production environments and R&D. This HPLC method can be adopted as general approach for analysis of basic compounds in various mixtures.

Condition

Column Primesep C, 3×50 mm, 5 µm, 100A
Mobile Phase MeCN
Buffer AmAc
Flow Rate 0.5 ml/min
Detection UV, 270 nm

 

 

Description

Class of Compounds
Drug, Analgetic, Acid, Hydrophilic, Ionizable,
Analyzing Compounds Acetaminophen, Pseudoephedrine, Guaifenesin
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Primesep C

The Primesep family of mixed-mode columns offer a wide variety of stationary phases with an unprecedented selectivity in the separation of a broad array of chemical compounds and in multiple applications. Corresponding Primesep guard columns are available with all stationary phases and do not require holders. SIELC offers a method development service which is available for all customers. Ask about our special custom LC-phases tailored for specific separations.

Select options
Application Analytes:
Acetaminophen (Paracetamol)
Guaifenesin
Phenylephrine

Application Detection:
UV Detection

HPLC Separation of Guaifenesin and Terbutaline

2006-06-05

SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.
Application Analytes:
Guaifenesin
Terbutaline

Application Detection:
UV Detection