Cefotaxime sodium

Cefotaxime sodium structural formula

CAS Number64485-93-4
Molecular FormulaC16H16N5NaO7S2
Molecular Weight477.441
  • Cefotaxime sodium
  • Sodium (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)-1-oxoethyl]amino]-8-oxo-, sodium salt, (6R,7R)- (1:1)
  • 64485-93-4
  • Cefotaxine sodium salt
  • Claforan sodium
  • EINECS 264-915-9
  • Sodium 7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)cephalosporanate
  • (+)-Cefotaxime sodium salt
  • Sodium cefotaxime
  • Tolycar
  • Cefotaxime sodium salt (syn-isomer)
  • Ralopar
  • Tolycor
  • Zariviz
  • Cefotaxime and dextrose 2.4% in plastic container
  • Cefotaxime and dextrose 3.9% in plastic container
  • Claforan in dextrose 5% in plastic container
  • Claforan in sodium chloride 0.9% in plastic container
  • UNII-258J72S7TZ


Separation of Cefotaxime sodium on Newcrom R1 HPLC column

February 16, 2018
Separation of Cefotaxime sodium on Newcrom C18 HPLC column

Cefotaxime sodium can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Cefotaxime sodium
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.