Tannic Acid

CAS Number1401-55-4
Molecular FormulaC76H52O46
Molecular Weight1701.206
InChI KeyLRBQNJMCXXYXIU-PPKXGCFTSA-N
LogP6.67
Synonyms
  • Tannic acid
  • [(2R,3R,4S,5R,6S)-3,4,5,6-Tetrakis({3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoyl}oxy)oxan-2-yl]methyl 3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoate (non-preferred name)
  • 1401-55-4
  • Acacia mollissima tannin
  • Acid, tannic
  • Castanea sativa Mill tannin
  • Caswell No. 819
  • EINECS 215-753-2
  • EPA Pesticide Chemical Code 078502
  • FEMA No. 3042
  • Gallotannic acid
  • Glycerite
  • Liquidambar styraciflua
  • Quebracho wood extract
  • Schinopsis lorentzii tannin
  • Tannic acid (Quercus spp.)
  • Tannin from chestnut
  • Tannin from mimosa
  • Tannin from quebracho
  • Tannin from sweet gum
  • NSC 656273
  • Acide tannique
  • d'Acide tannique
  • UNII-28F9E0DJY6
  • 61790-06-5
  • 67167-65-1
  • 73891-88-0
  • 93615-37-3
  • 1041198-33-7
  • 1041198-44-0

Applications:

HPLC Separation of Phenylephrine with Tannic Acid Formulation

November 21, 2010


Phenylephrine is a hydrophilic basic compound. Phenylephrine is used primarily as a decongestant in cough composition. Tannic acid is poly-phenolic compound. Tannic acid is also used to produce tannate salts of certain antihistamins and anti-tussives to impart increased stability or slow release properties to the API (active pharmaceutical ingredient). Phenylephrine in the presence of tannic acid is analyzed by mixed-mode HPLC on a Primesep 100 column. Retention time for phenylephrine is controlled by the amount of acetonitrile and buffer concentration. Tannic acid elutes closer to void and not interferes with analysis of phenylephrine. Method can be used with UV detection.

Application Column

Primesep 100

The Primesep family of mixed-mode columns offers a wide variety of stationary phases, boasting unprecedented selectivity in the separation of a broad array of chemical compounds across multiple applications. Corresponding Primesep guard columns, available with all stationary phases, do not require holders. SIELC provides a method development service available to all customers. Inquire about our specially-tailored custom LC-phases for specific separations.

Select options
Application Analytes:
Phenylephrine
Tannic Acid
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.