Vilazodone

CAS Number163521-12-8
Molecular Formula C26H27N5O2
Molecular Weight441.535
InChI KeySGEGOXDYSFKCPT-UHFFFAOYSA-N
LogP4
Synonyms
  • Vilazodone
  • 163521-12-8
  • 5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide
  • vilazodona
  • EMD 515259
  • vilazodonum
  • 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide
  • EMD-515259
  • EMD-68-843
  • 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide
  • EMD 68843 BASE
  • S239O2OOV3
  • CHEBI:70707
  • DTXSID80870086
  • 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide
  • 5-(4-(4-(5-Cyanoindol-3-yl)butyl)-1-piperazinyl)-2-benzofurancarboxamide
  • 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)piperazin-1-yl)-1-benzofuran-2-carboxamide
  • 5-{4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl}benzofuran-2-carboxamide
  • RefChem:56210
  • DTXCID10817924
  • N06AX24
  • 2-BENZOFURANCARBOXAMIDE, 5-[4-[4-(5-CYANO-1H-INDOL-3-YL)BUTYL]-1-PIPERAZINYL]-
  • MFCD09838919
  • CHEMBL439849
  • EMD-68843 BASE
  • Vilazodone [INN]
  • EMD 68843 (Hydrochloride);SB659746A (Hydrochloride)
  • Vilazodone [USAN:INN]
  • UNII-S239O2OOV3
  • HSDB 8197
  • 2-BENZOFURANCARBOXAMIDE, 5-(4-(4-(5-CYANO-1H-INDOL-3-YL)BUTYL)-1-PIPERAZINYL)-
  • 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-Benzofurancarboxamide; 1-[4-(5-Cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine; EMD 515259; Vilazodone
  • YG7
  • Vilazodone (Standard)
  • VILAZODONE [MI]
  • Vilazodone (USAN/INN)
  • VILAZODONE [USAN]
  • VILAZODONE [VANDF]
  • VILAZODONE [MART.]
  • VILAZODONE [WHO-DD]
  • SCHEMBL650682
  • GTPL7427
  • orb1226013
  • orb1309142
  • SCHEMBL29357448
  • SCHEMBL30051446
  • yl}-1-benzofuran-2-carboxamide
  • EX-A174
  • GLXC-04566
  • HMS3744C03
  • HMS3886N05
  • HMS5085F13
  • BDBM50151982
  • EBC-27110
  • HY-14262R
  • s5858
  • 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine
  • AKOS015924744
  • CS-0550
  • DB06684
  • PB25213
  • SB 659746A
  • SB20296
  • NCGC00371130-03
  • NCGC00371130-05
  • NCGC00371130-06
  • AC-25886
  • AS-73542
  • DA-59010
  • HY-14262
  • EMD 68843;SB 659746A
  • NS00068607
  • V3444
  • D09698
  • AB01563299_01
  • EN300-7395058
  • F861988
  • L001518
  • Q408588
  • BRD-K58010567-003-01-4
  • BRD-K58010567-003-02-2
  • BRD-K58010567-003-03-0
  • 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-
  • F0001-2418
  • 1-[4-(5-cyanoindol-3-yl)butyl]4-(2-carbamoyl-benzofuran-5-yl)-piperazine
  • 5-{4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl}benzo-furan-2-carboxamide
  • 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoyl-benzofuran-5-yl)-piperazine
  • 5 -(4-(4-(5 -Cyano-1H-indol-3 -yl)butyl)piperazin-1 -yl)benzofuran-2-carboxamide
  • 5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1-yl}-benzofuran-2-carboxylic acid amide

Applications:

HPLC Method for Analysis of Vilazodone in Pharmaceutical Formulation on Primesep 100 Column

August 11, 2026

HPLC Method for Analysis of Vilazodone on Primesep 100 Column by SIELC Technologies

High Performance Liquid Chromatography (HPLC) Method for Analysis of Vilazodone.

Vilazodone is a serotonin modulator with the chemical formula C26H27N5O2. It is primarily used to treat major depressive disorder. You can find detailed UV spectra of Vilazodone and information about its various lambda maxima by visiting the following link.

Vilazodone can be retained and analyzed using the Primesep 100 stationary phase column. The analysis utilizes an isocratic method with a simple mobile phase consisting of water and acetonitrile (MeCN). Detection is performed using UV.

Condition

ColumnPrimesep 100, 4.6 x 150 mm, 5 µm, 100 A, dual ended
Mobile PhaseMeCN/H2O – 50/50
BufferH2SO4 – 0.2%
Flow Rate1.0 ml/min
DetectionUV 240 nm
Limit Of Detection*80 ppb
*LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.

Description

Class of CompoundsDrug
Analyzing CompoundsVilazodone

Application Column

Primesep 100

Column Diameter: 4.6 mm
Column Length: 150 mm
Particle Size: 5 µm
Pore Size: 100 A
Column options: dual ended

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Application Analytes:
Vilazodone
Application Detection:
UV Detection
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.

Uv-Vis Spectrum of Vilazodone

August 5, 2026

Access the UV-Vis Spectrum SIELC Library

If you are looking for optimized HPLC method to analyze Vilazodone check our HPLC Applications library

UV/Vis.: λmax: 202, 240, 372, 313 nm

For optimal results in HPLC analysis, it is recommended to measure absorbance at a wavelength that matches the absorption maximum of the compound(s) being analyzed. The UV spectrum shown can assist in selecting an appropriate wavelength for your analysis. Please note that certain mobile phases and buffers may block wavelengths below 230 nm, rendering absorbance measurement at these wavelengths ineffective. If detection below 230 nm is required, it is recommended to use acetonitrile and water as low UV-transparent mobile phases, with phosphoric acid and its salts, sulfuric acid, and TFA as buffers.
For some compounds, the UV-Vis Spectrum is affected by the pH of the mobile phase. The compound was dissolved in ethanol. This analysis was done with the mobile phase of hexane, IPA, and TFA.

This compound was diluted in a mixture of water and acetonitrile. The method was done with a mixture of water, acetonitrile, and a sulfuric acid buffer.

 

 

 

 

 

Application Analytes:
Vilazodone
SIELC Technologies usually develops more than one method for each compound. Therefore, this particular method may not be the best available method from our portfolio for your specific application. Before you decide to implement this method in your research, please send us an email to research@sielc.com so we can ensure you get optimal results for your compound/s of interest.