Timolol maleate salt

Timolol maleate salt structural formula

CAS Number26921-17-5
Molecular FormulaC17H28N4O7S
Molecular Weight432.490
InChI KeyWLRMANUAADYWEA-NWASOUNVSA-N
LogP1.41
Synonyms
  • Timolol maleate salt
  • (2Z)-But-2-enedioic acid--(2S)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol (1/1)
  • 2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (2S)-, (2Z)-2-butenedioate (1:1) (salt)
  • 26921-17-5
  • Blocadren
  • (-)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol maleate
  • EINECS 248-111-5
  • Timacor
  • l-Timolol maleate
  • Timoptic
  • Timoptic in Ocudose
  • Timoptic-XE
  • UNII-P8Y54F701R
  • (S)-timolol hydrogen maleate
  • timolol hydrogen maleate
  • timolol maleate
  • (S)-timolol maleate

Applications:

Separation of Timolol maleate salt on Newcrom R1 HPLC column

February 16, 2018
Separation of Timolol maleate salt on Newcrom C18 HPLC column

Timolol maleate salt can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Timolol maleate salt
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.