Silybin sodium hemisuccinate

Silybin sodium hemisuccinate structural formula

CAS Number55254-34-7
Molecular FormulaC33H28Na2O16
Molecular Weight726.552
InChI KeyYIDLJQVKFQDISS-DSGKQNAUSA-L
LogP2.44
Synonyms
  • Silybin sodium hemisuccinate
  • Disodium 4-{[(2R,3R)-6-{(2R,3R)-3-[(3-carboxylatopropanoyl)oxy]-5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl}-3-(4-hydroxy-3-methoxyphenyl)-2,3-dihydro-1,4-benzodioxin-2-yl]methoxy}-4-oxobutanoate
  • Butanedioic acid, mono[[(2R,3R)-6-[(2R,3R)-3-(3-carboxy-1-oxopropoxy)-3,4-dihydro-5,7-dihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-1,4-benzodioxin-2-yl]methyl] ester, sodium salt (1:2)
  • 55254-34-7
  • EINECS 259-554-9
  • SIHS sodium
  • Silibinin-2',3-dihydrogensuccinate sodium salt
  • Silybin dihemisuccinate disodium
  • Silybin disodium hemisuccinate
  • Silybin hemisuccinate sodium salt
  • Silybin sodium dihemisuccinate
  • UNII-7HXE061K9Z

Applications:

Separation of Silybin sodium hemisuccinate on Newcrom R1 HPLC column

May 16, 2018
Separation of Silybin sodium hemisuccinate on Newcrom R1 HPLC column

Silybin sodium hemisuccinate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Silybin sodium hemisuccinate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us before ordering the column as there may be a more suitable column alternative by either e-mail: support@sielc.com or by phone: 847-229-2629.