Scopolamine

Scopolamine structural formula

CAS Number51-34-3
Molecular FormulaC17H21NO4
Molecular Weight303.359
InChI KeySTECJAGHUSJQJN-FWXGHANASA-N
LogP0.98
Synonyms
  • Scopolamine
  • (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]non-7-yl ester, (alphaS)-
  • 51-34-3
  • 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-, (-)-tropate (ester)
  • (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (alphaS)-
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, [7(S)-(1alpha,2beta,4beta,5alpha,7beta)]-
  • 3-Oxa-9-azatricyclo[3.3.1.02,4]nonane, benzeneacetic acid deriv.
  • 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-tropa
  • SEE
  • Scop
  • Scopine tropate
  • Benzeneacetic acid, alpha-(hydroxymethyl)-, (1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl ester, (alphaS)-
  • (-)-Hyoscine
  • 6,7-Epoxytropine tropate
  • 6beta,7beta-Epoxy-3alpha-tropanyl S-(-)-tropate
  • 9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol (-)-tropate
  • Atrochin
  • Atroquin
  • hioscina
  • Hyoscin
  • hyoscine
  • /-Scopolamine
  • Scopine (-)-tropate
  • Scopoderm TTS
  • Transcop
  • Transderm-Scop
  • Tropic acid ester with scopine
  • EINECS 200-090-3
  • 6beta,7beta-Epoxy-1alpha,5alpha-tropan-3alpha-ol
  • 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate
  • alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester
  • Skopolamin
  • 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,
  • Tropic acid, ester with scopine
  • Tropic acid, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4))non-7-yl ester
  • Transderm SCOP
  • UNII-DL48G20X8X
  • Boro-Scopol
  • Scopace
  • Hydrobromicum, Scopolaminum
  • (+)-Scopolamine
  • (-)-Hyoscine hydrobromide
  • (-)-Scopolamine bromide
  • (-)-Scopolamine hydrobromide
  • (-)-scopolamine
  • (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0²,???]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate
  • (1S,3S,5R,6R,7S)-6,7-epoxytropan-3-yl (2S)-3-hydroxy-2-phenylpropanoate
  • 6-beta,7-beta-Epoxy-3-alpha-tropanyl S-(-)-tropate
  • Beldavrin
  • Buscopan
  • Epoxytropine tropate
  • Euscopol
  • Hydroscine hydrobromide
  • Hyosceine
  • Hyoscine bromide
  • Hyoscine hydrobromide
  • Hyoscyine hydrobromide
  • Hyosol
  • Hysco
  • Isopto Hyoscine
  • Isoscopil
  • Kwells
  • L-Hyoscine hydrobromide
  • L-Scopolamine-hydrobromide
  • Methscopolamine Bromide
  • Oscine
  • Pamine
  • S-(-)-Tropate
  • Scopamin
  • Scopolamine bromide
  • Scopolamine hydrobromide
  • Scopolaminium bromide
  • Scopolammonium bromide
  • Tranaxine
  • alpha-(Hydroxymethyl)benzeneacetic acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2.4))non-7-yl ester
  • 14797-94-5
  • 28901-63-5
  • 58670-87-4
  • 65319-33-7
  • 97991-84-9
  • 226562-00-1

Applications:

Separation of Scopolamine on Newcrom R1 HPLC column

February 16, 2018
Separation of Scopolamine on Newcrom C18 HPLC column

Scopolamine can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Scopolamine
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.