Retinal structural formula

CAS Number116-31-4
Molecular FormulaC20H28O
Molecular Weight284.443
  • Retinal
  • 116-31-4
  • trans-Retinal
  • Vitamin A aldehyde
  • 4-07-00-01253
  • (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal
  • 2,4,6,8-Nonatetraenal, 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-
  • all-E-Retinal
  • all-trans-Retinal
  • all-trans-Retinaldehyde
  • all-trans-Vitamin A aldehyde
  • Axerophthal
  • E-Retinal
  • Retinal, all-trans-
  • retinaldehido
  • Retinaldehyd
  • Retinaldehyde
  • Retinene
  • trans-Vitamin A aldehyde
  • Vitamin A1 aldehyde
  • BRN 1914183
  • EINECS 204-135-8
  • NSC 122757
  • Retinyl aldehyde
  • NSC 626581
  • UNII-RR725D715M
  • Retinal, all-trans
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
  • All-epsilon-Retinal
  • Retinene 1
  • all-trans-retinaldehyde
  • alpha-Retinene
  • epsilon-Retinal
  • 7058-59-5


Separation of Retinal on Newcrom R1 HPLC column

February 16, 2018
Separation of Retinal on Newcrom C18 HPLC column

Retinal, also known as retinaldehyde, forms the basis of vision along with proteins called opsins. Certain organisms use retinal in the conversion of light into energy. Retinal can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: or by phone: 847-229-2629.