| CAS Number | 57-83-0 |
|---|---|
| Molecular Formula | C21H30O2 |
| Molecular Weight | 314.469 |
| InChI Key | RJKFOVLPORLFTN-LEKSSAKUSA-N |
| LogP | 3.87 |
| Synonyms |
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Applications:
Separation of Progesterone on Newcrom R1 HPLC column
February 16, 2018
Progesterone is a female sex hormone along with estrogen. It is involved in regulating menstrual cycle, pregnancy, and embryogenesis. Furan can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particle columns are available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation of impurities in preparative separation. It also suitable for pharmacokinetics.
Application Column
Newcrom R1
The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.
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