Prednisolone sodium succinate

Prednisolone sodium succinate structural formula

CAS Number1715-33-9
Molecular FormulaC25H31NaO8
Molecular Weight482.506
InChI KeyFKKAEMQFOIDZNY-CODXZCKSSA-M
LogP1.33
Synonyms
  • Prednisolone sodium succinate
  • Sodium 4-{[(11beta)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl]oxy}-4-oxobutanoate
  • Butanedioic acid, mono[(11beta)-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl] ester, sodium salt (1:1)
  • 1715-33-9
  • Di-Adreson F-aquosum
  • EINECS 216-995-1
  • Methyprednisolone sodium succinate
  • Meticortelane
  • Meticortelone, soluble
  • NSC 9151
  • Prednisolone 21-hemisuccinate sodium
  • Prednisolone 21-hemisuccinate sodium salt
  • Prednisolone sodium hemisuccinate
  • Prednisolone sodium 21-hemisuccinate
  • Prednisolone 21-sodium succinate
  • Prednisolone sodium succinate, injection
  • Prednisolone 21-succinate sodium
  • Predonine soluble
  • Sodium prednisolone 21-hemisuccinate
  • Solu-Decortin
  • UNII-8223RR9DWF

Applications:

Separation of Prednisolone sodium succinate on Newcrom R1 HPLC column

May 16, 2018
Separation of Prednisolone sodium succinate on Newcrom R1 HPLC column

Prednisolone sodium succinate can be analyzed by this reverse phase (RP) HPLC method with simple conditions. The mobile phase contains an acetonitrile (MeCN), water, and phosphoric acid. For Mass-Spec (MS) compatible applications the phosphoric acid needs to be replaced with formic acid. Smaller 3 µm particles columns available for fast UPLC applications. This liquid chromatography method is scalable and can be used for isolation impurities in preparative separation. It also suitable for pharmacokinetics.

Application Column

Newcrom R1

The Newcrom columns are a family of reverse-phase-based columns. Newcrom A, AH, B, and BH are all mixed-mode columns with either positive or negative ion-pairing groups attached to either short (25 Å) or long (100 Å) ligand chains. Newcrom R1 is a special reverse-phase column with low silanol activity.

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Application Analytes:
Prednisolone sodium succinate
The result was obtained by a proprietary SIELC algorithm. It may deviate from the actual experimental data. The experimental data are available upon request. Contact us by e-mail: support@sielc.com or by phone: 847-229-2629.